[toc] Urolithin A is a postbiotic—a compound our gut microbes can form from ellagitannins and ellagic acid, polyphenols found in foods such as pomegranates, strawberries, and walnuts. Because production depends on the presence of specific gut microbes, people fall into distinct "metabotypes" (A = good UA producers, B = partial producers, 0 = non-producers), and only a minority make large amounts from diet alone. Therefore, purified UA supplements bypass that microbiome variability.[ref doi='10.3389/fmicb.2017.01521'] Mechanistically UA is best known as an inducer of mitophagy—the selective au... immune system gut aging prebiotics urolithin a microbiome
Read moreDepression (https://www.foundmyfitness.com/topics/depression) is one of the most common mental health disorders worldwide—and one of the most debilitating. While conventional treatments like medication and cognitive behavioral therapy (CBT) can be effective, a growing body of research shows that physical activity deserves a seat at the table as a first-line treatment. A new meta-analysis examining 26 randomized controlled trials found that both aerobic and resistance training significantly reduced depressive symptoms—often to a degree comparable with more traditional interventions. Importantl... mental health anxiety exercise depression serotonin
Read moreDr. Kerry Courneya and Dr. Rhonda Patrick discuss the remarkable science behind exercise oncology. ... cancer exercise
Watch now[toc] Alcohol is one of the most heavily used and abused drugs. It's also a very controversial topic, in part because alcohol plays such a large role in societies and cultures around the world. For many, it's a normal part of daily life. There is also a lot of confusion about alcohol. There's no doubt that alcohol can have a personal and public health impact. On the other hand, research in the last few decades suggests that not only may a moderate intake of alcohol not be harmful, but it might also be protective against certain diseases. This idea is heavily debated, and conflicting evidence h... cancer cardiovascular alcohol brain alzheimer's diabetes breast cancer
Read more[toc position='left'] Protein is one of nutrition's most essential and debated topics. It goes far beyond its reputation as the building block of muscle, playing a crucial role in metabolism, insulin sensitivity, and the prevention of diseases like type 2 diabetes and sarcopenia. But questions abound: How much protein is enough, and can too much, particularly from animal sources, be harmful? Protein intake, paired with resistance training, drives muscle repair and growth, enhancing athletic performance, improving metabolic health, and promoting longevity by protecting against age-related frai... protein nutrition muscle exercise aging strength
Read more[toc position='left'] Introduction Omega-3 fatty acids are polyunsaturated fats that play critical roles in human health, participating in a wide range of biochemical pathways and processes and modulating the expression of genes throughout the lifespan. Omega-3 fatty acids include plant-derived alpha-linolenic acid (ALA) and marine-derived eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), among others. A growing body of evidence indicates that omega-3 fatty acids may prevent or ameliorate symptoms associated with chronic health conditions such as cardiovascular disease,[ref doi='10.3... cancer depression mortality omega-3 nutrition brain diet aging immune system mental health development intelligence
Read moreDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session. ... rhonda ketosis heart disease omega-3 fasting pregnancy eyes muscle sauna protein dairy intestinal permeability brown fat moringa supplements
Watch now[toc position='left'] Senescence is a response to stress in which damaged cells terminate normal growth cycles to prevent dysfunctional cells from reproducing. Senescence is a vital cellular process involved in embryonic development, wound healing, and cancer immunity; [ref doi='10.1242/dev.151837'] however, the accumulation of senescent cells is associated with diseases of aging such as cancer, cardiovascular disease, type 2 diabetes, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, sarcopenia, and glaucoma.[ref doi='10.1016/j.cell.2017.05.015'] [ref doi='10.3390/ijms19102937'] ... neurodegeneration senescence aging
Read moreDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session. ... rhonda vitamin d exercise parkinson's epigenetics omega-3 fasting melatonin vaccine resveratrol sauna insulin covid-19 cardiovascular autoimmunity Hair
Watch now[toc position='left'] > Epigenetic clocks are a subset of the broader subject of biological aging clocks, which you can read a full write-up on here (/topics/biological-age-clocks). Epigenetic clocks are predictors of biological age based on alterations in an individual's DNA methylation profile. Methylations – biochemical processes that modify the activity of a DNA segment without changing its sequence – occur naturally and regulate gene expression to control normal growth and development. With age, the methylation state of various genes may change. These changes are quantifiable and gauge... aging interesting epigenetics dna damage
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