The biology associated with dementia extends beyond the brain to inflammation, metabolism, and blood-vessel health. Researchers investigated whether semaglutide could alter a blood-protein pattern linked to future dementia. Researchers analyzed stored blood samples from 2,970 adults aged 65 or older who had participated in the randomized SELECT trial. All were overweight or obese and had established cardiovascular disease, but not diabetes. Participants received weekly semaglutide injections or matched placebo alongside standard care. Blood collected at the start and after 104 weeks was asses... alzheimer's cardiovascular dementia GLP-1 insulin obesity
Read moreAnecdotal reports from people with Parkinson’s suggest that time spent at high altitudes, where oxygen is naturally lower, may bring unexpected relief from symptoms. Researchers set out to investigate why. They injected mice with preformed clumps of α-synuclein, a protein that misfolds, accumulates, and damages brain cells in Parkinson’s disease, then housed them in either normal air (21% oxygen) or reduced oxygen (11%, roughly equivalent to oxygen availability near Everest Base Camp). Continuous low-oxygen exposure produced notable benefits: Low-oxygen exposure preserved neurons and prevented... brain hypoxia mitochondria neurodegeneration parkinson's
Read moreProteins in milk, meat, and other foods can trigger allergic reactions in some people. However, these proteins—called antigens—can also interact with the immune system to suppress small intestinal tumors. A recent study in mice found that food antigens help activate immune responses in the small intestine, potentially reducing the risk of tumors. Researchers fed mice genetically prone to developing intestinal tumors—similar to the genetic predisposition to familial adenomatous polyposis in humans—an antigen-free diet to pinpoint the role of food components in immune activation. They also depl... cancer diet immune system allergies protein
Read moreMaintaining muscle mass as we age requires a comprehensive approach encompassing nutrition and regular physical activity. However, many older adults don't consume adequate dietary protein and may lead sedentary lives, due to injuries, chronic illnesses, or joint problems. A recent study found that older adults who increased their dietary protein intake and engaged in regular exercise showed marked improvements in multiple health and fitness parameters. The study involved 97 older adults (average age, 64) with low dietary protein intake (less than 1 gram per kilogram of body weight daily) who ... nutrition exercise diet aging muscle protein
Read morePoor sleep negatively affects metabolism, impairing glucose tolerance and increasing the risk of developing type 2 diabetes. Findings from a recent study indicate that HIIT compensates for the harmful effects of sleep loss on glucose tolerance. Researchers assigned 24 healthy young men to one of three five-night sleep protocols: normal sleep (eight hours nightly), sleep restriction (four hours nightly), and sleep restriction with HIIT. Researchers collected muscle biopsies to assess muscle protein synthesis before and after the intervention. They found that the group with sleep restriction ex... exercise metabolism sleep diabetes circadian rhythm mitochondria
Read moreSleep deprivation profoundly affects the human body, negatively influencing cognitive performance, cardiovascular health, and more. Findings from a 2020 study suggest that sleep deprivation impairs muscle protein synthesis, but exercise counters this effect. People who slept only four hours per night but engaged in high-intensity interval training (HIIT) exhibited muscle protein synthesis comparable to those who slept a full night. Researchers assigned 24 healthy young men to one of three five-night sleep protocols: normal sleep (eight hours nightly), sleep restriction (four hours nightly), a... exercise sleep muscle protein aerobic
Read moreHeat shock proteins suppress amyloid-beta toxicity in the brain. Amyloid-beta is a toxic peptide that aggregates and forms plaques in the brain with age. These plaques are widely considered a hallmark of Alzheimer's disease, a progressive neurodegenerative disease that occurs with age and is the most common cause of dementia. Findings from a 2016 study suggest that heat shock proteins suppress amyloid-beta toxicity in the brain. Heat-shock proteins comprise a large, highly conserved family of proteins that are present in all cells, across many species. They play prominent roles in many cellu... brain alzheimer's heat stress sauna neurodegeneration
Read moreDr. Peter Diamandis and Tony Robbins discuss the application of precision medicine and health technologies in slowing human aging. ... aging cancer epigenetics performance immune system crispr
Watch nowCOVID-19 Q&A Series Part 1: Rhonda Patrick, Ph.D. addresses subscriber questions in this multi-part series. ... covid-19 vitamin d vitamin c virus melatonin sauna autoimmunity
Watch nowDr. Rhonda Patrick makes her second appearance on the Joe Rogan Experience. ... rhonda vitamin d nutrition brain diet obesity epigenetics aging sleep dna damage vitamin e sauna
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