What if deafness could be treated with a single injection instead of a lifelong device? A new clinical trial tested whether gene therapy could improve hearing in people born with mutations in a key hearing gene. The study included 10 participants aged 1.5 to 23.9 with a condition called OTOF-related hearing loss. The OTOF gene provides instructions for making otoferlin, a protein that allows inner ear cells to send signals to the auditory nerve. When otoferlin is missing or not working properly, sound can still be detected by the ear, but the signal is not properly transmitted to the brain. To... genetic engineering hearing
Read moreDr. Rhonda Patrick and Dr. Charles Brenner discuss NAD precursors, NR versus NMN, NAD IV drips, and what truly boosts NAD for recovery and longevity. ... nad+ pregnancy dna damage aging resveratrol oxidative stress
Watch nowDepression is one of the most common and disabling conditions among young adults, yet current treatments often fail to address potential metabolic factors that may underlie symptoms. Researchers tested whether a ketogenic diet could support standard care in college students with major depressive disorder. The study enrolled 24 students with clinician-confirmed depression; 16 completed the 10–12 week intervention while continuing their usual treatment. Participants received support to follow the ketogenic diet (less than 50 grams of carbohydrate per day, moderate protein, and fats), including ... bdnf depression ketogenic diet ketosis mental health
Read moreDr. Andrew Huberman discusses the role of dopamine in driving motivation and offers practical tools for enhancing mood and focus. ... brain exercise diet performance alcohol adhd cold stress dopamine supplements
Watch nowIn my keynote at LongevityFest 2023, I share powerful habits to delay aging and improve healthspan, presented at the American Academy of Anti-Aging Medicine. ... aging vitamin d exercise omega-3 micronutrients magnesium bdnf
Watch nowDr. Martin Gibala discusses HIIT's health benefits and describes common HIIT protocols. ... exercise aging heart disease diabetes mitochondria cortisol fat muscle bone lactate exercise snacks
Watch now[toc position='left'] Small vessel disease is a condition causing blood vessel dysfunction that occurs with aging and contributes to the development of cardiovascular disease, dementia, and stroke. As a consequence of the profound effects of small vessel disease on the functioning of the brain and blood-brain barrier (/topics/blood-brain-barrier), for the purposes of this article, we will focus predominantly on cerebral aspects of small vessel disease, called cerebral small vessel disease. Small vessel disease in the brain contributes to approximately 50 percent of dementia cases worldwide, in... small vessel disease brain alzheimer's vitamin d omega-3 parkinson's inflammation cardiovascular blood-brain barrier
Read moreEndurance and resistance training are associated with distinct hormonal signatures Exercise is widely accepted to be beneficial to our health. Research finds it to have a positive dose-dependent impact (https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-020-09855-3) on factors varying from cognitive function and bone strength to all-cause mortality and metabolic health. But does the specific mode of exercise make a difference? A 2018 study suggests that resistance and endurance exercise engage largely distinct hormonal responses in the body. It also highlights endurance trainin... exercise metabolism hormones fgf21
Read more[toc position='left'] Brain-derived neurotrophic factor, or BDNF, is a growth factor relevant to aging, brain function, behavior, metabolism, energy expenditure, and satiety. BDNF serves as a cell signaling protein, plays vital roles in numerous signaling pathways associated with a variety of disorders ranging from depression, (https://www.foundmyfitness.com/topics/depression) schizophrenia, and addiction to obesity and diabetes, and may serve as a hormone. It is perhaps best known for its influence on the formation, growth, survival, and development of neurons and for its role in mediating th... exercise omega-3 meditation brain alzheimer's parkinson's fasting memory interesting
Read moreA special two-hour Q&A with Dr. Jed Fahey, an expert on sulforaphane, chemoprotection, and phytochemicals. ... sulforaphane brain cancer performance dna damage antioxidant nrf2 moringa
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