[toc] Alcohol is one of the most heavily used and abused drugs. It's also a very controversial topic, in part because alcohol plays such a large role in societies and cultures around the world. For many, it's a normal part of daily life. There is also a lot of confusion about alcohol. There's no doubt that alcohol can have a personal and public health impact. On the other hand, research in the last few decades suggests that not only may a moderate intake of alcohol not be harmful, but it might also be protective against certain diseases. This idea is heavily debated, and conflicting evidence h... cancer cardiovascular alcohol brain alzheimer's diabetes breast cancer
Read more[toc position='left'] Introduction Light has profound and diverse effects on the human body, influencing sleep-wake cycles, circadian rhythmicity, mood, and immune function. In recent decades, scientists have begun exploiting the body's responses to light with photobiomodulation, a non-invasive, light-based therapeutic technique. Photobiomodulation employs specific wavelengths of light (measured in nanometers, nm) to stimulate biological processes within cells and tissues, triggering a cascade of physiological responses. A growing body of evidence suggests that photobiomodulation has potential... bone skin brain depression arthritis
Read more[toc position='left'] Toll-like receptors are a family of pattern recognition receptors expressed on the surface of immune and other cells. Toll-like receptors are the principal inducers of innate immunity[ref doi='10.1186/cc1471'], activating transcription factors such as NF-kB that increase the expression of inflammatory cytokines. Among toll-like receptors, TLR4 is notable for recognizing lipopolysaccharide (LPS), a structure found on the outer membranes of Gram-negative bacteria. This overview will predominantly focus on TLR4 and its involvement in human health, disease, and behavior. Toll... toll-like receptors gut aging microbiome inflammation immune system intestinal permeability omega-3 endotoxemia
Read more[toc position='left'] Aging refers to the collective physiological, functional, and mental changes that accrue in a biological organism over time. The hallmarks of aging are observable biological patterns of dysfunction that occur with aging. Integral to the aging process is inflammaging, the chronic, low-grade inflammation that occurs with aging.[ref doi='10.1111/j.1749-6632.2000.tb06651.x'] The mechanisms that drive inflammaging and the pathological conditions that arise because of it are bidirectional and involve multiple physiological processes and pathways, many of which directly or indir... mitochondria aging omega-3 stem cells aerobic senescence
Read more[toc position='left'] Senescence is a response to stress in which damaged cells terminate normal growth cycles to prevent dysfunctional cells from reproducing. Senescence is a vital cellular process involved in embryonic development, wound healing, and cancer immunity; [ref doi='10.1242/dev.151837'] however, the accumulation of senescent cells is associated with diseases of aging such as cancer, cardiovascular disease, type 2 diabetes, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, sarcopenia, and glaucoma.[ref doi='10.1016/j.cell.2017.05.015'] [ref doi='doi.org/10.3390/ijms1910... neurodegeneration senescence aging
Read more[toc position='left'] Background [tweetbox text='"Because BHB is involved in such foundational cellular functions as gene regulation, increasing BHB concentrations may be protective against a wide range of diseases."' tweet='"Because BHB is involved in such foundational cellular functions as gene regulation, increasing BHB concentrations may be protective against a wide range of diseases." https://www.foundmyfitness.com/topics/beta-hydroxybutyrate'] Beta-hydroxybutyrate (BHB) is an endogenous (i.e., produced by the body) ketone produced via the breakdown of fats during times of carbohydrate sc... butyrate exercise fasting aging ketosis
Read more[toc position='left'] Butyrate (from the Ancient Greek word for "butter") is a short-chain fatty acid (SCFA) that occurs naturally in butter and other foods and is also produced by microbes in the gut. Microbial production of short-chain fatty acids, including acetate and propionate, occurs in the colon during the fermentation of indigestible fibers found in plant foods such as legumes, fruits, nuts, cereals, and whole grains. In the gut, butyrate is the preferred fuel source for colonocytes, the skin-like cells that line the colon.[ref pmid='21978911'] Butyrate participates in a wide array of... exercise fasting butyrate gut microbiome ketosis immune system intestinal permeability
Read more[toc position='left'] Introduction Vitamin D is a fat-soluble vitamin that is stored in the liver and fatty tissues of the body. Perhaps best known for its role in maintaining calcium balance and bone health, vitamin D is critical in many physiological processes, such as blood pressure regulation, immune function, and cell growth. Poor vitamin D status is implicated in the pathogenesis of many acute and chronic diseases, including rickets, osteoporosis, multiple sclerosis, and cancer. Vitamin D is a controversial topic in the scientific community and has contributed to much debate regarding t... gut blood pressure vitamin d aging vitamin k calcium
Read more[toc position='left'] Background Quercetin is a bioactive compound that exerts antioxidant and anti-inflammatory properties.[ref pmid='26393898'] Research indicates that quercetin may alleviate chronic health conditions such as hypertension, neurodegenerative disease, arthritis, and lung and kidney diseases and may be beneficial in combating aging-related diseases. Although much of the quercetin research has been performed in animals, some clinical trials have been conducted, and others are ongoing. A naturally occurring member of the flavonoid class of plant polyphenol (https://www.foundmyfi... aging antioxidant nutrition inflammation
Read more[toc position='left'] Bathing oneself in heat for the purposes of purification, cleansing, and healing is an ancient practice, dating back thousands of years and observed across many cultures. Variations of its use are seen today in the banyas of Russia, the sweat lodges of the American Indians, and, most famously, the saunas of Finland. Sauna use, sometimes referred to as "sauna bathing," is characterized by short-term passive exposure to extreme heat. This exposure elicits mild hyperthermia – an increase in the body's core temperature – that induces a thermoregulatory response involving neu... exercise inflammation sauna aging performance depression bisphenol a heat stress interesting alzheimer's
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