[toc position='left'] Introduction Light does much more than help us see. It tells the brain what time it is. That signal coordinates sleep and wakefulness, hormone release, metabolism, mood, and hundreds of other processes that follow a roughly 24-hour rhythm. Its effects depend not simply on how much light reaches the eye, but when it arrives. Bright light in the morning and throughout the day strengthens the body's daytime signal. Dim evenings and dark nights allow the biological night to unfold. Modern life often reverses that pattern, giving us biologically dim days and unusually bright n... metabolism sleep depression mental health melatonin eyes circadian rhythm
Read more[toc position='left'] Creatine (https://www.foundmyfitness.com/topics/creatine) is a naturally occurring compound that is critical in storing and releasing cellular energy. It also participates in many biological processes driving pregnancy outcomes, maintaining bone mineral density and muscle mass in older adults, improving neurological function, and aiding the immune system to fight cancer. Creatine is best known for its widespread use as a dietary supplement to enhance physical performance. Creatine, phosphocreatine, creatine transporters, and creatine kinase enzymes are expressed in the en... cardiovascular heart disease
Read more[toc position='left'] Introduction Magnesium is an essential dietary mineral. It plays critical roles in myriad physiological processes, serving as a cofactor to more than 300 enzymes in the human body and maintaining the integrity of cellular structures and DNA. Magnesium deficiency is widespread, affecting more than half of people in the U.S. and increasing the risk of many chronic conditions, including cancer, metabolic disorders, and neurodegenerative diseases. At a glance, magnesium participates in: Enzymatic reactions, serving as a cofactor for more than 300 enzymes involved in variou... magnesium brain nutrition supplements micronutrients
Read moreDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session. ... rhonda exercise gut aging omega-3 inflammation fasting cold stress senescence supplements
Watch now[toc position='left'] Creatine is a naturally occurring compound that is critical in storing and releasing cellular energy. It also participates in many biological processes driving pregnancy outcomes, maintaining bone mineral density and muscle mass in older adults, improving neurological function, and aiding the immune system to fight cancer. Creatine is best known for its widespread use as a dietary supplement to enhance physical performance. Creatine uptake, synthesis, storage, and supplementation Creatine uptake Creatine can be supplied exogenously (from dietary or supplemental sources) ... metabolism neurodegeneration nutrition brain aging depression pregnancy
Read more[toc position='left'] > Epigenetic clocks are a subset of the broader subject of biological aging clocks, which you can read a full write-up on here (/topics/biological-age-clocks). Epigenetic clocks are predictors of biological age based on alterations in an individual's DNA methylation profile. Methylations – biochemical processes that modify the activity of a DNA segment without changing its sequence – occur naturally and regulate gene expression to control normal growth and development. With age, the methylation state of various genes may change. These changes are quantifiable and gauge... aging interesting epigenetics dna damage
Read more[toc position='left'] Metformin is a drug commonly used to treat type 2 diabetes. It is the fourth most widely prescribed medication in the United States, with more than 80 million prescriptions for the drug written yearly. Metformin is in a class of drugs called biguanides, which impede liver gluconeogenesis (glucose production in the liver), thereby decreasing glucose uptake in the gut and increasing overall glucose utilization by improving insulin sensitivity in skeletal muscle and fat tissue. Multiple studies demonstrate that metformin reduces fasting blood glucose levels by as much as 3.9... exercise aging diabetes
Read more[toc position='left'] Hyperthermia, a state of elevated core body temperature, stresses the body, activating molecular mechanisms that mitigate protein damage and aggregation and promote endogenous antioxidant, repair, and degradation processes. Whole-body hyperthermia is a therapeutic strategy used to treat various medical conditions, including cancer, fibromyalgia, and others.[ref doi='10.1093/annonc/mdf280'][ref doi='10.2147/CIA.S74949'][ref doi='10.3205/000235'] Emerging evidence suggests that whole-body hyperthermia might be useful in treating depression.[ref doi='10.1001/jamapsychiatry.2... sauna cancer depression
Read moreDr. Satchin Panda discusses the practical aspects of implementing fasting, time-restricted eating, shift work strategies, and more. ... fasting cancer obesity metabolism diabetes circadian rhythm melatonin time-restricted eating
Watch nowTIMELINE: 00:03:22 (https://www.youtube.com/watch?v=Gm626MgpveI&t=00h03m22s) - How genetically inhibiting autophagy actually increases cellular sensitivity to death and how this was counterintuitive because autophagy was thought, at one time, as a type of activity predominantly concerned with actually initiating cell death. 00:04:44 (https://www.youtube.com/watch?v=Gm626MgpveI&t=00h04m44s) - The external signals causing autophagy. 00:05:29 (https://www.youtube.com/watch?v=Gm626MgpveI&t=00h05m29s) - The role of growth factors in transporting nutrients from the outside world into the...
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