Q&A #18 with Dr. Rhonda Patrick (12/5/2020)

        00:03:12 - Rhonda shares her anecdote about how adding moringa powder lowered her blood glucose. [1](https://www.foundmyfitness.com/episodes/jed-fahey-q-a)
00:05:20 - **Q:** What are your thoughts on the recent study that showed _hyperbaric oxygen treatment could reverse specific biomarkers of aging?_ [**1**](https://www.aging-us.com/article/202188/text#r11)
00:07:04 - As cells age, they lose their protective telomeres and cells become senescent. [1](https://www.foundmyfitness.com/episodes/judy-campisi)
00:15:25 - **Q:** What are your thoughts on this recent paper showing _worse glycemic control after a night of fragmented sleep when coffee is consumed before a meal?_ [**1**](https://doi.org/10.1017/S0007114520001865)
00:16:16 - Coffee consumption can have beneficial effects on glycemic control. [1](https://www.biogreenscience.com/file/clinical/bioscfit/cs_bioscfit_4.pdf) [2](https://care.diabetesjournals.org/content/32/6/1023) [3](https://pubmed.ncbi.nlm.nih.gov/24459154/)
00:16:50 - Caffeine by itself can have negative effects on glycemic control. [1](https://care.diabetesjournals.org/content/29/2/398.short) [2](https://jamanetwork.com/journals/jama/article-abstract/201177?casa_token=V2IDyYc1XQ4AAAAA:8fGJYsxBEEn3RLHvQ5-YRbkLoyy4AGPFSzk0IgAsIvvzPkQN-puuRYTBsLeOjELhWm-oq_BN) [3](https://diabetes.diabetesjournals.org/content/50/10/2349.short) [4](https://care.diabetesjournals.org/content/25/2/364.short)
00:17:55 - Coffee beans lose polyphenol content the more they are processed. [1](https://www.researchgate.net/publication/26296017_Role_of_Roasting_Conditions_in_the_Level_of_Chlorogenic_Acid_Content_in_Coffee_Beans_Correlation_with_Coffee_Acidity#:~:text=Roasting%20temperature%20is%20ranging%20from,can%20be%20detected%20%5B1%5D%20.)
00:18:46 - Fragmented sleep can cause poorer glycemic control. [1](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557027/) [2](https://academic.oup.com/jcem/article/95/6/2963/2598810)
00:21:10 - **Q:** Is there a way to control parathyroid hormone to improve calcium sensitivity and reduce the progression of arteriosclerosis and osteoporosis?
00:21:47 - Function of parathyroid hormone in the body.
00:25:45 - **Q:** What are your thoughts on food inflammation tests that measure IgG and immune complexes?
00:27:33 - IgG antibodies to food do not correlate with food allergies. [1](https://docs.google.com/document/d/1WehS1e-Xc8pd_ov_2WuRKYNW-KOfxmq4eZJKs9guUnk/edit#) [2](https://pubmed.ncbi.nlm.nih.gov/19577283/)
00:28:54 - **Q:** Are there any risks for hyperbaric oxygen treatment?
00:30:17 - **Q:** What are the pros and cons of different forms of magnesium supplements present on the market?
00:31:45 - Magnesium oxide
00:32:33 - Magnesium chloride [1](https://journals.lww.com/americantherapeutics/Abstract/2001/09000/Bioavailability_and_Pharmacokinetics_of_Magnesium.8.aspx) [2](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180067)
00:32:59 - Magnesium glycinate [1](https://pubmed.ncbi.nlm.nih.gov/30541089/)
00:33:53 - Magnesium citrate [1](https://journals.lww.com/americantherapeutics/Abstract/2001/09000/Bioavailability_and_Pharmacokinetics_of_Magnesium.8.aspx)
00:34:06 - Dietary magnesium [1](https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en10) [2](https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en10)
00:34:47 - Magnesium threonate [1](https://pubmed.ncbi.nlm.nih.gov/20152124/) [2](https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.15-275578) [3](https://www.ncbi.nlm.nih.gov/pubmed/26519439)
00:36:36 - Magnesium malate [1](https://link.springer.com/article/10.1007/s12011-018-1351-9#Sec11) and magnesium sulfate
00:39:08 - **Q:** If my blood levels of magnesium are normal, is there still a benefit to supplementing?
00:41:50 - _Severe magnesium deficiency was associated with a 32% increase in all-cause mortality_. [1](https://www.ahajournals.org/doi/abs/10.1161/circ.133.suppl_1.p146)
00:43:00 - **Q:** Do omega-3 fatty acids EPA and DHA compete for absorption and should they be taken separately?
00:44:18 - **Q:** Which test panel to choose for measuring cholesterol? Total cholesterol with HDL, LDL, and very low DL vs. apo A/ apo B.
00:46:33 - **Rhonda's crash course on blood lipid particles.** [1](https://www.foundmyfitness.com/episodes/ronald-krauss)
00:56:40 - _Fish oil supplementation has been shown to decrease apo B levels in people with dyslipidemia._ [1](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543286/)
00:59:53 - **Q:** Most supplement companies are focusing on producing keto products that are predominantly composed of C8 (caprylic acid) medium-chain triglycerides. What potential benefits are being missed out on by not taking C10 (capric acid) and C12 (lauric acid) medium-chain triglycerides?
00:59:52 - Metabolism of dietary medium-chain fatty acids.
01:04:05 - Caprylic acid (C8) is being researched as a therapeutic for essential tremor [1](https://n.neurology.org/content/80/10/933) [2](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811161/) [3](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592780/), but may negatively affect the gut microbiome.[1](https://pubmed.ncbi.nlm.nih.gov/19096058/) [2](https://pubmed.ncbi.nlm.nih.gov/26135893/) [3](https://pubmed.ncbi.nlm.nih.gov/20181443/)
01:04:47 - Capric acid (C10) is being researched as a therapy for epilepsy. [1](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805082/#awv325-B7) [2](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805082/#awv325-B7)
01:05:11 - Lauric acid (C12) is a medium-chain fatty acid found in high concentrations in coconut oil that has been shown to reduce hunger when taken with tryptophan [1](https://pubmed.ncbi.nlm.nih.gov/31051504/) [2](https://pubmed.ncbi.nlm.nih.gov/31703434/) and to have mixed effects on cardiovascular health. [1](https://academic.oup.com/ajcn/article/77/5/1146/4689813?ijkey=846a72387ebc0d82545acd5442a0c3a9e9fc3566)
01:07:38 - **Q:** Is it necessary to measure lactate levels to gauge exercise intensity? [1](https://www.foundmyfitness.com/episodes/george-brooks)
01:09:27 - _Heart rate increases linearly with exercise intensity while lactate increases exponentially_. [1](https://www.ncbi.nlm.nih.gov/pubmed/3678222)
01:10:32 - **Q:** Does consuming medium-chain fatty acids increase LDL?
01:11:50 - **Q:** Is there a threshold amount of sun exposure necessary before DNA damage occurs? Or does damage begin immediately when sunlight hits the skin? Is there a level of "UV index" where it begins to matter?
01:17:05 - **Q:** Our daughter is 4 months old. When I start to introduce foods (in addition to breastmilk, of course), I’m curious about what to feed her. I notice that you put fish oil supplements into your son’s meals. Could you talk about your experience in this arena? [1](https://www.foundmyfitness.com/episodes/breast-milk) [2](https://www.foundmyfitness.com/topics/breastfeeding)
01:21:04 - **Q:** Is it possible to get enough DHA through supplementation if you are a vegetarian or vegan?
01:23:12 - **Q:** Can fasting/time-restricted feeding delay menopause in women and how may it affect egg quality over time?
01:28:09 - **Rapid fire questions**
01:28:09 - **Q:** Are there any supplements that are beneficial for eye health?
01:28:50 - **Q:** Would consuming moringa as a hot tea inactivate its myrosinase?
01:29:11 - **Q:** Does a Berkey filter safely filter tap water?
01:29:57 - **Q:** For the 99.9% of us that don’t have access to NPure3 supplements, what other omega-3 supplements would you recommend or would you buy?
01:32:30 - **Q:** What are your thoughts on standing desks?
01:33:25 - **Q:** How much vitamin C should a healthy person supplement with?
01:35:54 - **Q:** Which foods are best for getting collagen? [1](https://www.foundmyfitness.com/topics/collagen)