Carbohydrate availability describes whether dietary carbohydrate and the body's carbohydrate stores—especially liver and muscle glycogen—are sufficient for the demands of exercise, recovery, and daily metabolism. It is not the same as energy availability, which describes the dietary energy remaining after exercise relative to fat-free mass. A person can consume enough total calories yet still have low carbohydrate availability if carbohydrate is replaced largely by fat. Why carbohydrate availability matters Carbohydrate supplies blood glucose and replenishes glycogen, the stored carbohydrate t... exercise diet metabolism muscle bone carbohydrates
Read more[toc position='left'] Biological aging clocks are among the most important tools in modern longevity science. They attempt to answer a deceptively simple question: can we measure how fast a person is aging biologically, rather than just counting the number of years they have been alive? The answer is yes—but with important caveats. Epigenetic clocks use patterns of DNA methylation, a chemical tagging system on DNA, to estimate different aspects of aging. Some clocks estimate chronological age. Others predict disease risk, mortality risk, or the current pace of biological aging. This means biol... epigenetics aging telomeres genetics stem cells omega-3 dna damage biomarkers vitamin d senescence multivitamin
Read more[toc] Alcohol is one of the most heavily used and abused drugs. It's also a very controversial topic, in part because alcohol plays such a large role in societies and cultures around the world. For many, it's a normal part of daily life. There is also a lot of confusion about alcohol. There's no doubt that alcohol can have a personal and public health impact. On the other hand, research in the last few decades suggests that not only may a moderate intake of alcohol not be harmful, but it might also be protective against certain diseases. This idea is heavily debated, and conflicting evidence h... cancer cardiovascular alcohol brain alzheimer's diabetes breast cancer
Read moreTime-restricted eating involves consuming meals within a specific daily time window but is distinct from true fasting, which involves extended food abstinenc... ... aliquot exercise fasting muscle time-restricted eating protein
Listen nowIt's tempting to think of dementia as something in the long-distant future – a condition that only affects older people. But the factors that drive dementia ... ... aliquot exercise brain aging omega-3 inflammation dementia
Listen now[toc position='left'] The blood-brain barrier comprises various membranes that separate the central nervous system (CNS) and the peripheral circulatory system. The purpose of this barrier is to allow the passage of nutrients and cell signals from the bloodstream to nerves and supporting cells in the CNS while excluding harmful substances. Genetic predispositions, environmental exposures, and aging may weaken the integrity of this barrier, allowing endotoxins and inflammatory immune cells to infiltrate the brain, contributing to accelerated brain aging and the risk of neurodegenerative diseases... omega-3 immune system blood-brain barrier brain alzheimer's gut obesity
Read more[toc position='left'] Introduction Vitamin D is a fat-soluble vitamin that is stored in the liver and fatty tissues of the body. Perhaps best known for its role in maintaining calcium balance and bone health, vitamin D is critical in many physiological processes, such as blood pressure regulation, immune function, and cell growth. Poor vitamin D status is implicated in the pathogenesis of many acute and chronic diseases, including rickets, osteoporosis, multiple sclerosis, and cancer. Vitamin D is a controversial topic in the scientific community and has contributed to much debate regarding t... gut blood pressure vitamin d aging vitamin k calcium
Read more[toc position='left'] Background Zinc is an essential nutrient that participates in numerous biological processes and modulates the activity of more than 300 enzymes and 2,000 transcription factors.[ref doi='10.1136/bmj.326.7386.409'] First identified for its influence on growth and development, zinc is now understood to play critical roles in immune function, protein synthesis, wound healing, DNA synthesis, and cell division. History The importance of zinc in the human diet first became apparent in the early 1960s, after a patient with a rare syndrome presented to Dr. Ananda Prasad, a physic... nutrition interesting zinc
Read more[toc position='left'] Introduction [tweetbox text='"Modulation of autophagy may represent a promising therapeutic approach for extending human lifespan and healthspan."' tweet='"Modulation of autophagy may represent a promising therapeutic approach for extending human lifespan and healthspan." https://www.foundmyfitness.com/topics/autophagy'] Homeostasis, a cell's ability to maintain a constant internal environment, is essential to cell survival. It is predicated on achieving an equilibrium between the production and degradation of cellular components. One major pathway for degradation is auto... aging mitochondria autophagy nutrition exercise parkinson's cancer autoimmunity
Read moreFOXO proteins are members of the FOX family of highly conserved transcriptional regulators. They play essential roles in human lifespan and healthy aging, influenced by environmental and genetic factors. The genetic contribution to lifespan and aging increases with time, suggesting that people who live long lives might carry so-called "protective genes." Run the longevity report to learn more about genetic polymorphisms influencing the expression of FOXO (/genetics) Background FOX proteins are named for a gene found in fruit flies that causes the insects to have forked structures on their head... aging fasting nutrition diet
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