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    <a data-turbo="false" href="/episodes/aliquot-138-sleep-supplements-and-substances">
      <h3 class="bold">
        [Podcast] Aliquot #138: Why Sedation Isn&#39;t Sleep and What Actually Works
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      Many of the substances people use to relax, sleep, or stay alert quietly reshape the biology of sleep...
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          <span class="search-tag">aliquot</span>
          <span class="search-tag">alcohol</span>
          <span class="search-tag">melatonin</span>
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          <span class="search-tag">sleep</span>
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    <a data-turbo="false" href="/topics/high-protein-diet">
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        [Topic] High-Protein Diets
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This post originally went out to subscribers to the FoundMyFitness newsletter. Sign up here to start receiving it! (https://www.foundmyfitness.com/newsletter)
Protein is still (somehow) controversial.
Should we restrict protein in favor of longevity and reducing cancer risk, or should we maximize our intake in favor of building muscle mass and enhancing performance?
The answer lies somewhere in the middle. But one thing is for certain—the current recommendations don&#39;t accurately reflect the scientific evidence.
That&#39;s why I sat down with Dr. Peter Attia as a guest on his ...
          <span class="search-tag">aging</span>
          <span class="search-tag">cancer</span>
          <span class="search-tag">muscle</span>
          <span class="search-tag">strength</span>
          <span class="search-tag">protein</span>
          <span class="search-tag">exercise</span>
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        [Topic] Choline
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Choline is an essential nutrient critical for various bodily functions, including brain development, liver health, and muscle function. It acts as a precursor to acetylcholine, a neurotransmitter involved in memory, attention, and muscle control. Choline also contributes to the synthesis of phospholipid membranes and serves as a source of methyl groups necessary for metabolic processes. While the body can produce small amounts of choline, most of it must come from the diet to meet physiological needs.
The benefits of choline are wide-ranging. During pregnancy, adequate ch...
          <span class="search-tag">brain</span>
          <span class="search-tag">blood-brain barrier</span>
          <span class="search-tag">alzheimer&#39;s</span>
          <span class="search-tag">acetylcholine</span>
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        [Topic] Melatonin
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Introduction
Melatonin isn’t just the “sleep hormone”—it regulates over 500 genes and plays a key role in the body’s antioxidant defenses.
As we age, melatonin production declines significantly. By the time a person reaches 50 years old, melatonin levels are 50% of what they were at age 20. By age 80, melatonin production can be ten times lower than in teenagers. (https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.888292/full) This reduction in melatonin is linked to changes in sleep patterns, circadian rhythm disruption, and overall healt...
          <span class="search-tag">melatonin</span>
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          <span class="search-tag">parkinson&#39;s</span>
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          <span class="search-tag">circadian rhythm</span>
          <span class="search-tag">dementia</span>
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        [Topic] Sulforaphane
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Sulforaphane is a bioactive compound derived from certain cruciferous vegetables, particularly broccoli (and its sprouts) and red kale. Robust evidence from epidemiological, clinical, rodent, and in vitro studies has demonstrated that sulforaphane exhibits antioxidant and anti-inflammatory properties and may be beneficial against a wide range of chronic and acute diseases, including autism, cancer, metabolic dysfunction, and many others and may ameliorate some of the harmful effects associated with exposure to air pollution.  
Sulforaphane exerts its therapeutic effects t...
          <span class="search-tag">sulforaphane</span>
          <span class="search-tag">cancer</span>
          <span class="search-tag">behavior</span>
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          <span class="search-tag">breast cancer</span>
          <span class="search-tag">inflammation</span>
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          <span class="search-tag">antioxidant</span>
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        [Podcast] Q&amp;A #19: Rhonda’s Time-Restricted Eating Window—Inflammation &amp; Longer Fasts
      </h3>
</a>    <p>
      Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&amp;amp;A session.
...
          <span class="search-tag">rhonda</span>
          <span class="search-tag">vitamin d</span>
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          <span class="search-tag">vitamin c</span>
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          <span class="search-tag">covid-19</span>
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        [Topic] Breast milk and breastfeeding 
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Nutrition in the first year of life is crucial to an infant&#39;s development and lifelong health. Early nutritional deficits are intrinsically linked to impaired mental and physical growth. Consequently, the risk of developing metabolic and cardiovascular diseases such as obesity, diabetes, and hypertension in childhood and later life is likely determined by early feeding and nutritional status. 
Breastfeeding is the biologically superior way to feed an infant. The American Academy of Pediatrics recommends exclusive breastfeeding for the first six months of an infant&#39;s life ...
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          <span class="search-tag">heart disease</span>
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          <span class="search-tag">inflammation</span>
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          <span class="search-tag">stem cells</span>
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        [Topic] Caloric restriction
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Caloric restriction is the practice of long-term reduced dietary intake, typically characterized by a 20 to 50 percent decrease in caloric intake below habitual levels, without malnutrition or deprivation of essential nutrients. It involves a consistent pattern of reducing average daily caloric intake and differs from fasting and other restrictive eating patterns in that the latter regimens primarily focus on the frequency and timing of eating rather than a pattern of permanent, long-term restriction.
Caloric restriction in animals
Caloric restriction delays the onset of ...
          <span class="search-tag">diet</span>
          <span class="search-tag">aging</span>
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        [Topic] Resveratrol
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Resveratrol is a natural compound found primarily in the skin of red grapes and the root of Polygonum cuspidatum (also known as Japanese knotweed). It is also present to a lesser degree in peanuts and blueberries. Resveratrol protects the plants in which it is present from fungal attack and the damaging effects of ultraviolet radiation. 
Originally extracted in the 1940s, resveratrol attracted little interest in terms of human health until 1992 when research suggested that it could mediate some of the cardioprotective effects of red wine.[ref doi=&#39;10.3390/molecules220202...
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          <span class="search-tag">alzheimer&#39;s</span>
          <span class="search-tag">metabolism</span>
          <span class="search-tag">cardiovascular</span>
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        [Topic] Time-restricted eating
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Time-restricted eating is a form of daily fasting wherein the time of the day during which a person eats is limited, or compressed. People who practice time-restricted eating typically eat during an 8- to 12-hour daytime window and fast during the remaining 12 to 16 hours. Unlike intermittent fasting, which involves caloric restriction, time-restricted eating permits a person to eat as much as they want during the eating window. Time-restricted eating aligns the eating and fasting cycles to the body’s innate 24-hour circadian system.[ref doi=&#39;10.3390/ijms20081911&#39;] Within...
          <span class="search-tag">fasting</span>
          <span class="search-tag">diet</span>
          <span class="search-tag">metabolism</span>
          <span class="search-tag">sleep</span>
          <span class="search-tag">circadian rhythm</span>
          <span class="search-tag">interesting</span>
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