Aliquot #138: Why Sedation Isn't Sleep and What Actually Works

Posted on November 25th 2025 (3 months)
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Aliquot #138: Why Sedation Isn't Sleep and What Actually Works

Many of the substances people use to relax, sleep, or stay alert quietly reshape the biology of sleep itself. From THC, CBD, alcohol, caffeine, and nicotine to melatonin, magnesium, glycine, and calming botanicals, these compounds can either support restorative sleep or subtly hijack it, changing REM, deep sleep, and circadian timing in ways we often do not feel until the next day. In this aliquot, Dr. Michael Grandner and I explore how common substances affect sleep — and how adjusting timing, dose, or choosing better alternatives can improve your nightly recovery.

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