Aliquot #138: Why Sedation Isn't Sleep and What Actually Works

Posted on November 25th 2025 (10 days)
For our premium members

Aliquot #138: Why Sedation Isn't Sleep and What Actually Works

Many of the substances people use to relax, sleep, or stay alert quietly reshape the biology of sleep itself. From THC, CBD, alcohol, caffeine, and nicotine to melatonin, magnesium, glycine, and calming botanicals, these compounds can either support restorative sleep or subtly hijack it, changing REM, deep sleep, and circadian timing in ways we often do not feel until the next day. In this aliquot, Dr. Michael Grandner and I explore how common substances affect sleep — and how adjusting timing, dose, or choosing better alternatives can improve your nightly recovery.

00:00:00
View chapters

This is an exclusive members-only episode.
Learn more about the FoundMyFitness premium membership here.

Are you already a member?
Click here to login

This is a members-only episode. Learn more about FoundMyFitness premium: Become a member

Get these episodes in a convenient podcast format.

Aliquot episodes make great companion listening for a long drive. You can find these special members-only episodes alongside live recorded Q&As on The Aliquot, our official premium FoundMyFitness podcast.

Hear new content from Rhonda on The Aliquot, our member's only podcast

Listen in on our regularly curated interview segments called "Aliquots" released every week on our premium podcast The Aliquot. Aliquots come in two flavors: features and mashups.

  • Hours of deep dive on topics like fasting, sauna, child development surfaced from our enormous collection of members-only Q&A episodes.
  • Important conversational highlights from our interviews with extra commentary and value. Short but salient.

Recent Aliquot Episodes

Posted on 10/24/2025

Aliquot #137: How to Optimize Iron without Causing Overload

Iron plays a central role in health across the lifespan. It forms the core of hemoglobin, the molecule in red blood cells...

aliquot
genetics
aging
iron
development
supplements
neurodegeneration
brain
alcohol
Posted on 10/07/2025

Aliquot #136: How Micronutrient Deficiencies Accelerate Aging

Micronutrient deficiencies, even mild ones, can quietly erode health over decades, raising the risk of chronic disease. One framework...

aliquot
magnesium
vitamin d
vitamin e
acetylcholine
vitamin k
supplements
Posted on 09/30/2025

Aliquot #135: Creatine Myths and Misconceptions

Creatine supplementation has long been shrouded in myths and misconceptions, ranging from dehydration and kidney damage to hair loss...

aliquot
homocysteine
muscle
supplements
Posted on 09/11/2025

Aliquot #134: Why Homocysteine Accelerates Brain Aging

Elevated homocysteine levels often slip under the radar during routine checkups, yet they quietly raise our risk...

vitamin b12
heart disease
folate
nitric oxide
homocysteine
blood pressure
Posted on 08/15/2025

Aliquot #133: The Surprising Effects of Creatine on the Brain

Creatine plays a key role in maintaining cellular energy balance, and evidence suggests it can help the brain...

stress
aging
concussion
neurodegeneration
brain
depression