[toc] Coffee is more than just a morning ritual or a comforting pick-me-up—it's a scientifically supported pathway to improved health, performance, and longevity. As one of the world's most widely consumed beverages, coffee has long been celebrated for its energizing properties. However, emerging research now highlights its remarkable potential to extend lifespan, slow biological aging, and reduce the risk of chronic diseases like heart disease, diabetes, and certain cancers. Coffee reduces the body's biological age by modulating gene expression and protects against cardiovascular events and n... alzheimer's diabetes parkinson's caffeine neurodegeneration cardiovascular metabolism coffee L-Theanine
Read more[toc position='left'] Around age 50, muscle strength—the ability to exert force or lift a heavy resistance—drops by about 3% per year, while muscle mass falls by about 1% per year.[ref doi='10.14283/jfa.2016.78'] The fix to this is simple: Resistance training and an adequate protein intake (https://www.foundmyfitness.com/episodes/protein). Engaging in strength training 2–3 times per week and consuming 1.2–1.6 grams of protein per kilogram of body weight per day can help one maintain—and even build—muscle mass and muscle strength as they age. It's not inevitable that we lose muscle as we get ol... aging muscle exercise
Read moreMitochondria are best known for their energy-producing roles, but they also help regulate cellular metabolism, signaling, and apoptosis... ... aliquot Ubiquinol diet aging metabolism mitochondria apoptosis supplements
Listen nowDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session. ... rhonda alzheimer's aging sleep alcohol skin sauna protein ketogenic diet cocoa Ubiquinol
Watch now[toc position='left'] Introduction Omega-3 fatty acids are polyunsaturated fats that play critical roles in human health, participating in a wide range of biochemical pathways and processes and modulating the expression of genes throughout the lifespan. Omega-3 fatty acids include plant-derived alpha-linolenic acid (ALA) and marine-derived eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), among others. A growing body of evidence indicates that omega-3 fatty acids may prevent or ameliorate symptoms associated with chronic health conditions such as cardiovascular disease,[ref doi='10.3... cancer depression mortality omega-3 nutrition brain diet aging immune system mental health development intelligence
Read more[toc position='left'] Introduction Lactobacillus reuteri is a bacterium found in the digestive tracts of mammals, including humans, and in fermented foods. It is a member of the genus Lactobacillus, which comprises most of the bacteria that live on and in the human body. Lactic acid-producing bacteria, such as those in the Lactobacillus genus, are commonly used in probiotic supplements.[ref doi='10.1016/j.tim.2021.01.003'] Furthermore, some online resources provide step-by-step instructions for at-home bulk production of yogurt with L. reuteri enrichment. (https://drdavisinfinitehealth.com/201... gut probiotics microbiome
Read more[toc position='left'] Polyphenols comprise a group of antioxidant compounds found in a variety of plants consumed as foods and beverages. Polyphenols are one of the most common classes of bioactive compounds found in plants, along with alkaloids (e.g., berberine (https://www.foundmyfitness.com/topics/berberine)), organosulfur compounds (e.g., sulforaphane), and terpenoids (e.g., beta carotene). A growing body of evidence suggests that polyphenols have disease-fighting properties, although the evidence to support these claims varies in quality. Research has demonstrated some degree of efficacy ... polyphenol brain cancer heart disease green tea gut diet microbiome microbes
Read more[toc position='left'] N-glycolylneuraminic acid, or Neu5Gc, is a sialic acid – a nine-carbon sugar molecule – produced by most nonhuman mammals. Sialic acids serve diverse roles, such as mediating cell-to-cell interactions, triggering cell signaling cascades, and binding to pathogens.[ref doi='10.1016/j.molmed.2008.06.002'] Humans do not produce Neu5Gc; however, trace amounts of the compound are commonly present in human urine, suggesting that Neu5Gc is obtained in the diet. Foods highest in Neu5Gc include red meat and milk. It is rarely present in fish or poultry, but eggs are rich in Neu5Ac... diet nutrition cancer inflammation
Read more[toc position='left'] > Epigenetic clocks are a subset of the broader subject of biological aging clocks, which you can read a full write-up on here (/topics/biological-age-clocks). Epigenetic clocks are predictors of biological age based on alterations in an individual's DNA methylation profile. Methylations – biochemical processes that modify the activity of a DNA segment without changing its sequence – occur naturally and regulate gene expression to control normal growth and development. With age, the methylation state of various genes may change. These changes are quantifiable and gauge... aging interesting epigenetics dna damage
Read moreBefore you jump right into the timeline here's a few useful links: Tim's blog post for the episode (http://fourhourworkweek.com/2014/06/10/the-tim-ferriss-show-rhonda-patrick-life-extension/), a direct link to the audio file (http://traffic.libsyn.com/timferriss/Episode12_TFS.mp3), and if you haven't already... make sure to signup for the FMF newsletter (see the footer of this page), and grab the FoundMyFitness iPhone app (https://itunes.apple.com/us/app/foundmyfitness-nutrition-science/id859601167). One last note: you may post this anywhere you like!! To make it easier for you to do so... cli...
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