[toc position='left'] Choline is an essential nutrient critical for various bodily functions, including brain development, liver health, and muscle function. It acts as a precursor to acetylcholine, a neurotransmitter involved in memory, attention, and muscle control. Choline also contributes to the synthesis of phospholipid membranes and serves as a source of methyl groups necessary for metabolic processes. While the body can produce small amounts of choline, most of it must come from the diet to meet physiological needs. The benefits of choline are wide-ranging. During pregnancy, adequate ch... brain blood-brain barrier alzheimer's acetylcholine
Read moreDr. Layne Norton and I discuss fat loss, resistance training, seed oils, the carnivore diet, artificial sweeteners, and much more. ... exercise nutrition obesity metabolism muscle polyunsaturated fat saturated fat time-restricted eating protein weight loss strength supplements
Watch nowIn this episode, we’re taking a deep dive into alcohol. We’ll explore the science, misconceptions, controversies, and health effects of this widely used drug. ... alcohol exercise brain alzheimer's cancer aging microbiome sleep heart disease
Watch nowCholine, an essential nutrient found in eggs, meat, fish, beans, and nuts, supports the production of acetylcholine, a neurotransmitter involved in neurogenesis, synapse formation, learning, and memory. Most people living in the US don't consume enough choline – 550 milligrams per day for men and 425 milligrams per day for women – potentially increasing their risk for various diseases (https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/#h5). A 2019 study in mice found that lifelong choline supplementation prevented Alzheimer's disease and preserved cognitive function. Researchers f... nutrition alzheimer's diet aging micronutrients neurotransmitter acetylcholine
Read more[toc position='left'] Senescence is a response to stress in which damaged cells terminate normal growth cycles to prevent dysfunctional cells from reproducing. Senescence is a vital cellular process involved in embryonic development, wound healing, and cancer immunity; [ref doi='10.1242/dev.151837'] however, the accumulation of senescent cells is associated with diseases of aging such as cancer, cardiovascular disease, type 2 diabetes, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, sarcopenia, and glaucoma.[ref doi='10.1016/j.cell.2017.05.015'] [ref doi='10.3390/ijms19102937'] ... neurodegeneration senescence aging
Read moreDepression and anxiety are neuropsychiatric diseases characterized by neurological dysfunction and poor mental health. Oxidative stress, which is caused by an imbalance in the concentration of reactive oxygen species and antioxidant compounds, may be one driver of neurological damage in the development of depression and anxiety. Findings of a new report demonstrate the ability of methyl donor supplementation to reduce oxidative stress in the brain and relieve depression and anxiety symptoms in rats eating a high-sugar diet. Methyl donors (e.g., choline, betaine, folate, vitamin B12) are nutrie... brain depression anxiety
Read moreAge-related diseases like heart disease, diabetes, dementia, and cancers are on the rise, placing a significant burden on the healthcare system and economy. Interventions that can slow the aging process by just two years could save almost $7 trillion over 50 years and increase health and quality of life. Authors of a recent report tested the effects of a diet and lifestyle intervention on the reversal of epigenetic aging. Epigenetic aging is a way to predict an individual’s risk of age-related disease by biological means instead of just chronology. Epigenetics is a biological mechanism that re... epigenetics aging
Read moreAbnormal aggregates of tau, a protein found in the brain, are one of the defining characteristics of Alzheimer’s disease. These aggregates, known as tau tangles, inhibit normal brain function. The degree of cognitive impairment in Alzheimer’s disease is correlated with their presence. Findings from a new study suggest that hydrogen sulfide prevents tau tangle formation by inhibiting tau phosphorylation. Hydrogen sulfide is a naturally occurring gas, notable for its strong odor of rotten eggs. Exposure to hydrogen sulfide can cause irritation to the eyes and respiratory system. Hydrogen sulfide... alzheimer's
Read more[toc position='left'] N-glycolylneuraminic acid, or Neu5Gc, is a sialic acid – a nine-carbon sugar molecule – produced by most nonhuman mammals. Sialic acids serve diverse roles, such as mediating cell-to-cell interactions, triggering cell signaling cascades, and binding to pathogens.[ref doi='10.1016/j.molmed.2008.06.002'] Humans do not produce Neu5Gc; however, trace amounts of the compound are commonly present in human urine, suggesting that Neu5Gc is obtained in the diet. Foods highest in Neu5Gc include red meat and milk. It is rarely present in fish or poultry, but eggs are rich in Neu5Ac... diet nutrition cancer inflammation
Read more[toc position='left'] Salmon roe – sometimes referred to as "salmon caviar" – is the internal egg mass found in female salmon. It is served in a variety of dishes, including sushi and pasta, or as a garnish or condiment to seafood or eggs. Salmon roe is rich in protein, vitamins, astaxanthin, and the omega-3 fatty acids eicosapentaenoic acid, or EPA, and docosahexaenoic acid, or DHA. Omega-3 fatty acids are long-chain polyunsaturated fatty acids. They are considered essential fatty acids because the human body cannot make them. Alpha-linolenic acid, or ALA, an omega-3 fatty acid that serves a... brain aging omega-3 diet mental health dementia alzheimer's
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