[toc position='left'] Protein is one of nutrition's most essential and debated topics. It goes far beyond its reputation as the building block of muscle, playing a crucial role in metabolism, insulin sensitivity, and the prevention of diseases like type 2 diabetes and sarcopenia. But questions abound: How much protein is enough, and can too much, particularly from animal sources, be harmful? Protein intake, paired with resistance training, drives muscle repair and growth, enhancing athletic performance, improving metabolic health, and promoting longevity by protecting against age-related frai... protein nutrition muscle exercise aging strength
Read more[toc position='left'] Introduction Microplastics are everywhere: in the food we eat, the water we drink, and even the air we breathe. Imagine consuming the equivalent of a credit card’s worth of plastic every week—just by going about your daily routine. As startling as it may seem, this is the reality we face, exposing our bodies to a hidden threat that’s growing by the day. What are microplastics? They're tiny pieces of plastic or other polymer-based materials, ranging from 5 millimeters (~0.2 inches) to as small as 100 nanometers, often called nanoplastics. These tiny particles contain a var... environment brain diet cardiovascular Microplastics pollution PFAS
Read moreVitamins are substances that our bodies need to develop and function normally. When considering vitamins, we tend to think of the usual suspects – A, C, D, E... ... aliquot cancer aging micronutrients mortality taurine
Listen now[toc position='left'] Small vessel disease is a condition causing blood vessel dysfunction that occurs with aging and contributes to the development of cardiovascular disease, dementia, and stroke. As a consequence of the profound effects of small vessel disease on the functioning of the brain and blood-brain barrier (/topics/blood-brain-barrier), for the purposes of this article, we will focus predominantly on cerebral aspects of small vessel disease, called cerebral small vessel disease. Small vessel disease in the brain contributes to approximately 50 percent of dementia cases worldwide, in... small vessel disease brain alzheimer's vitamin d omega-3 parkinson's inflammation cardiovascular blood-brain barrier
Read more[toc position='left'] Aging refers to the collective physiological, functional, and mental changes that accrue in a biological organism over time. The hallmarks of aging are observable biological patterns of dysfunction that occur with aging. Integral to the aging process is inflammaging, the chronic, low-grade inflammation that occurs with aging.[ref doi='10.1111/j.1749-6632.2000.tb06651.x'] The mechanisms that drive inflammaging and the pathological conditions that arise because of it are bidirectional and involve multiple physiological processes and pathways, many of which directly or indir... mitochondria aging omega-3 stem cells aerobic senescence
Read more[toc position='left'] Background [tweetbox text='"Because BHB is involved in such foundational cellular functions as gene regulation, increasing BHB concentrations may be protective against a wide range of diseases."' tweet='"Because BHB is involved in such foundational cellular functions as gene regulation, increasing BHB concentrations may be protective against a wide range of diseases." https://www.foundmyfitness.com/topics/beta-hydroxybutyrate'] Beta-hydroxybutyrate (BHB) is an endogenous (i.e., produced by the body) ketone produced via the breakdown of fats during times of carbohydrate sc... butyrate exercise fasting aging ketosis
Read more[toc position='left'] A single layer of epithelial cells lines the entire digestive tract, facilitating the exchange of nutrients between the intestine and the bloodstream. This layer, referred to as the intestinal epithelium, must be permeable to nutrients yet impermeable to pathogens. [tweetbox text='"Increased intestinal permeability (also known as "leaky gut") allows pathogens to leak through the intestinal barrier and pass directly into the bloodstream, promoting inflammation."' tweet='"Increased intestinal permeability (also known as "leaky gut") allows pathogens to leak through the int... intestinal permeability butyrate gut microbiome polyphenol autoimmunity
Read more[toc position='left'] Brain-derived neurotrophic factor, or BDNF, is a growth factor relevant to aging, brain function, behavior, metabolism, energy expenditure, and satiety. BDNF serves as a cell signaling protein, plays vital roles in numerous signaling pathways associated with a variety of disorders ranging from depression, (https://www.foundmyfitness.com/topics/depression) schizophrenia, and addiction to obesity and diabetes, and may serve as a hormone. It is perhaps best known for its influence on the formation, growth, survival, and development of neurons and for its role in mediating th... exercise omega-3 meditation brain alzheimer's parkinson's fasting memory interesting
Read more[toc position='left'] Bathing oneself in heat for the purposes of purification, cleansing, and healing is an ancient practice, dating back thousands of years and observed across many cultures. Variations of its use are seen today in the banyas of Russia, the sweat lodges of the American Indians, and, most famously, the saunas of Finland. Sauna use, sometimes referred to as "sauna bathing," is characterized by short-term passive exposure to extreme heat. This exposure elicits mild hyperthermia – an increase in the body's core temperature – that induces a thermoregulatory response involving neu... exercise inflammation sauna aging performance depression bisphenol a heat stress interesting alzheimer's
Read moreTIMELINE: 00:03:22 (https://www.youtube.com/watch?v=Gm626MgpveI&t=00h03m22s) - How genetically inhibiting autophagy actually increases cellular sensitivity to death and how this was counterintuitive because autophagy was thought, at one time, as a type of activity predominantly concerned with actually initiating cell death. 00:04:44 (https://www.youtube.com/watch?v=Gm626MgpveI&t=00h04m44s) - The external signals causing autophagy. 00:05:29 (https://www.youtube.com/watch?v=Gm626MgpveI&t=00h05m29s) - The role of growth factors in transporting nutrients from the outside world into the...
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