Drs. Rhonda Patrick and Darren Candow explain why one lean-mass trial does not overturn the broader creatine evidence. ... exercise performance muscle strength supplements creatine
Watch nowDr. Rhonda Patrick reviews coffee timing, mortality, cardiovascular health, diabetes, and possible epigenetic pathways. ... circadian rhythm coffee aging metabolism diabetes mortality cardiovascular
Watch nowVitamins are substances that our bodies need to develop and function normally. When considering vitamins, we tend to think of the usual suspects – A, C, D, E... ... aliquot cancer aging micronutrients mortality taurine
Listen nowIn this clip, Drs. Levine and Patrick discuss definitions of aging used in science and why biological aging matters to scientists. ... epigenetics aging
Watch now[toc position='left'] The blood-brain barrier comprises various membranes that separate the central nervous system (CNS) and the peripheral circulatory system. The purpose of this barrier is to allow the passage of nutrients and cell signals from the bloodstream to nerves and supporting cells in the CNS while excluding harmful substances. Genetic predispositions, environmental exposures, and aging may weaken the integrity of this barrier, allowing endotoxins and inflammatory immune cells to infiltrate the brain, contributing to accelerated brain aging and the risk of neurodegenerative diseases... omega-3 immune system blood-brain barrier brain alzheimer's gut obesity
Read more[toc position='left'] Toll-like receptors are a family of pattern recognition receptors expressed on the surface of immune and other cells. Toll-like receptors are the principal inducers of innate immunity[ref doi='10.1186/cc1471'], activating transcription factors such as NF-kB that increase the expression of inflammatory cytokines. Among toll-like receptors, TLR4 is notable for recognizing lipopolysaccharide (LPS), a structure found on the outer membranes of Gram-negative bacteria. This overview will predominantly focus on TLR4 and its involvement in human health, disease, and behavior. Toll... toll-like receptors gut aging microbiome inflammation immune system intestinal permeability omega-3 endotoxemia
Read more[toc position='left'] > Epigenetic clocks are a subset of the broader subject of biological aging clocks, which you can read a full write-up on here (/topics/biological-age-clocks). Epigenetic clocks are predictors of biological age based on alterations in an individual's DNA methylation profile. Methylations – biochemical processes that modify the activity of a DNA segment without changing its sequence – occur naturally and regulate gene expression to control normal growth and development. With age, the methylation state of various genes may change. These changes are quantifiable and gauge... aging interesting epigenetics dna damage
Read more[toc position='left'] Caloric restriction is the practice of long-term reduced dietary intake, typically characterized by a 20 to 50 percent decrease in caloric intake below habitual levels, without malnutrition or deprivation of essential nutrients. It involves a consistent pattern of reducing average daily caloric intake and differs from fasting and other restrictive eating patterns in that the latter regimens primarily focus on the frequency and timing of eating rather than a pattern of permanent, long-term restriction. Caloric restriction in animals Caloric restriction delays the onset of ... diet aging
Read more[toc position='left'] Nicotinamide mononucleotide (NMN) is a precursor molecule for the biosynthesis of nicotinamide adenine dinucleotide, or NAD+, a coenzyme that participates in the production of cellular energy and DNA repair. NAD+ can also be synthesized from other precursors including nicotinamide (NAM, also called niacinamide), nicotinic acid (NA), and nicotinamide riboside (NR), which are often collectively referred to as niacin (vitamin B3) or niacin equivalents.[ref doi='10.12688/f1000research.12120.1'] These precursors are not equally allocated throughout the body; rather, they exhib... aging obesity neurodegeneration exercise cancer dna damage mitochondria nad+ cardiovascular
Read more[toc position='left'] Fasting – the voluntary abstinence from food and drink – is an ancient tradition long believed to be vital to humans' physical and spiritual health. Practiced for millennia by various cultures and religious groups, fasting is now widely appreciated for its beneficial effects on human metabolism and healthspan.[ref doi='10.1194/jlr.P020867'] [ref doi='10.1016/j.cmet.2015.05.012'] [ref doi='10.1093/cdn/nzz044.P08-053-19'] A growing body of evidence suggests that in the absence of ready supplies of glucose and fats from meals, fasting flips a metabolic "switch," liberating f... obesity fasting nutrition diet aging circadian rhythm autophagy
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