[toc position='left'] Biological aging clocks are among the most important tools in modern longevity science. They attempt to answer a deceptively simple question: can we measure how fast a person is aging biologically, rather than just counting the number of years they have been alive? The answer is yes—but with important caveats. Epigenetic clocks use patterns of DNA methylation, a chemical tagging system on DNA, to estimate different aspects of aging. Some clocks estimate chronological age. Others predict disease risk, mortality risk, or the current pace of biological aging. This means biol... epigenetics aging telomeres genetics stem cells omega-3 dna damage biomarkers vitamin d senescence multivitamin
Read more[toc] Urolithin A is a postbiotic—a compound our gut microbes can form from ellagitannins and ellagic acid, polyphenols found in foods such as pomegranates, strawberries, and walnuts. Because production depends on the presence of specific gut microbes, people fall into distinct "metabotypes" (A = good UA producers, B = partial producers, 0 = non-producers), and only a minority make large amounts from diet alone. Therefore, purified UA supplements bypass that microbiome variability.[ref doi='10.3389/fmicb.2017.01521'] Mechanistically UA is best known as an inducer of mitophagy—the selective au... immune system gut aging prebiotics urolithin a microbiome
Read more[toc position='right'] When we engage in high-intensity exercise, our muscles become mini biochemical laboratories (https://www.youtube.com/watch?v=YXl1evV_spo), synthesizing compounds like lactate and myokines that circulate throughout the body and travel to our organs, where they exert a variety of signaling effects, including the synthesis of brain-derived neurotrophic factor (BDNF) (https://bdnfprotocols.com/)in the brain. Some of these molecules have anti-cancer properties. Vigorous exercise is also the most potent way to increase your VO2 max, also known as cardiorespiratory fitness, wh... exercise brain bdnf aerobic cardiovascular mortality aging exercise snacks
Read more[toc position='left'] Introduction Light has profound and diverse effects on the human body, influencing sleep-wake cycles, circadian rhythmicity, mood, and immune function. In recent decades, scientists have begun exploiting the body's responses to light with photobiomodulation, a non-invasive, light-based therapeutic technique. Photobiomodulation employs specific wavelengths of light (measured in nanometers, nm) to stimulate biological processes within cells and tissues, triggering a cascade of physiological responses. A growing body of evidence suggests that photobiomodulation has potential... bone skin brain depression arthritis
Read more[toc position='left'] Aging refers to the collective physiological, functional, and mental changes that accrue in a biological organism over time. The hallmarks of aging are observable biological patterns of dysfunction that occur with aging. Integral to the aging process is inflammaging, the chronic, low-grade inflammation that occurs with aging.[ref doi='10.1111/j.1749-6632.2000.tb06651.x'] The mechanisms that drive inflammaging and the pathological conditions that arise because of it are bidirectional and involve multiple physiological processes and pathways, many of which directly or indir... mitochondria aging omega-3 stem cells aerobic senescence
Read more[toc position='left'] Introduction [tweetbox text='"The beneficial effects of cold exposure may be due to hormesis, a favorable biological response to a mild stressor."' tweet='"The beneficial effects of cold exposure may be due to hormesis, a favorable biological response to a mild stressor." https://www.foundmyfitness.com/topics/cold-exposure-therapy'] Cold exposure to promote good health is an ancient practice, now used to reduce muscle soreness and promote muscle recovery after physical activity. However, regular cold exposure may also improve glucose and lipid metabolism, decrease inflamm... performance cholesterol immune system thermogenesis cold stress brain heart disease diabetes insulin resistance inflammation depression mitochondria neuron blood pressure interesting
Read more[toc position='left'] Introduction Vitamin D is a fat-soluble vitamin that is stored in the liver and fatty tissues of the body. Perhaps best known for its role in maintaining calcium balance and bone health, vitamin D is critical in many physiological processes, such as blood pressure regulation, immune function, and cell growth. Poor vitamin D status is implicated in the pathogenesis of many acute and chronic diseases, including rickets, osteoporosis, multiple sclerosis, and cancer. Vitamin D is a controversial topic in the scientific community and has contributed to much debate regarding t... gut blood pressure vitamin d aging vitamin k calcium
Read more[toc position='left'] Metformin is a drug commonly used to treat type 2 diabetes. It is the fourth most widely prescribed medication in the United States, with more than 80 million prescriptions for the drug written yearly. Metformin is in a class of drugs called biguanides, which impede liver gluconeogenesis (glucose production in the liver), thereby decreasing glucose uptake in the gut and increasing overall glucose utilization by improving insulin sensitivity in skeletal muscle and fat tissue. Multiple studies demonstrate that metformin reduces fasting blood glucose levels by as much as 3.9... exercise aging diabetes
Read more[toc position='left'] Introduction [tweetbox text='"Modulation of autophagy may represent a promising therapeutic approach for extending human lifespan and healthspan."' tweet='"Modulation of autophagy may represent a promising therapeutic approach for extending human lifespan and healthspan." https://www.foundmyfitness.com/topics/autophagy'] Homeostasis, a cell's ability to maintain a constant internal environment, is essential to cell survival. It is predicated on achieving an equilibrium between the production and degradation of cellular components. One major pathway for degradation is auto... aging mitochondria autophagy nutrition exercise parkinson's cancer autoimmunity
Read moreDr. Guido Kroemer discusses immunology, cancer biology, calorie-restriction mimetics, aging, and autophagy. ... aging nutrition cancer podcast fasting multiple sclerosis autophagy video triglycerides fatty liver time-restricted eating protein
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