[toc] Urolithin A is a postbiotic—a compound our gut microbes can form from ellagitannins and ellagic acid, polyphenols found in foods such as pomegranates, strawberries, and walnuts. Because production depends on the presence of specific gut microbes, people fall into distinct "metabotypes" (A = good UA producers, B = partial producers, 0 = non-producers), and only a minority make large amounts from diet alone. Therefore, purified UA supplements bypass that microbiome variability.[ref doi='10.3389/fmicb.2017.01521'] Mechanistically UA is best known as an inducer of mitophagy—the selective au... immune system gut aging prebiotics urolithin a microbiome
Read more[toc] Alcohol is one of the most heavily used and abused drugs. It's also a very controversial topic, in part because alcohol plays such a large role in societies and cultures around the world. For many, it's a normal part of daily life. There is also a lot of confusion about alcohol. There's no doubt that alcohol can have a personal and public health impact. On the other hand, research in the last few decades suggests that not only may a moderate intake of alcohol not be harmful, but it might also be protective against certain diseases. This idea is heavily debated, and conflicting evidence h... cancer cardiovascular alcohol brain alzheimer's diabetes breast cancer
Read more[toc position='right'] When we engage in high-intensity exercise, our muscles become mini biochemical laboratories (https://www.youtube.com/watch?v=YXl1evV_spo), synthesizing compounds like lactate and myokines that circulate throughout the body and travel to our organs, where they exert a variety of signaling effects, including the synthesis of brain-derived neurotrophic factor (BDNF) (https://bdnfprotocols.com/)in the brain. Some of these molecules have anti-cancer properties. Vigorous exercise is also the most potent way to increase your VO2 max, also known as cardiorespiratory fitness, wh... exercise brain bdnf aerobic cardiovascular mortality aging exercise snacks
Read moreDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session. ... rhonda exercise gut aging omega-3 inflammation fasting cold stress senescence supplements Hair
Watch nowDr. Patrick's keynote: compromised intestinal barrier affects human health—cardiometabolic function, neurological health, behavior, and more. ... intestinal permeability alzheimer's gut heart disease inflammation depression blood-brain barrier lipopolysaccharide
Watch now[toc position='left'] Introduction [tweetbox text='"The beneficial effects of cold exposure may be due to hormesis, a favorable biological response to a mild stressor."' tweet='"The beneficial effects of cold exposure may be due to hormesis, a favorable biological response to a mild stressor." https://www.foundmyfitness.com/topics/cold-exposure-therapy'] Cold exposure to promote good health is an ancient practice, now used to reduce muscle soreness and promote muscle recovery after physical activity. However, regular cold exposure may also improve glucose and lipid metabolism, decrease inflamm... performance cholesterol immune system thermogenesis cold stress brain heart disease diabetes insulin resistance inflammation depression mitochondria neuron blood pressure interesting
Read more[toc position='left'] Background Quercetin is a bioactive compound that exerts antioxidant and anti-inflammatory properties.[ref pmid='26393898'] Research indicates that quercetin may alleviate chronic health conditions such as hypertension, neurodegenerative disease, arthritis, and lung and kidney diseases and may be beneficial in combating aging-related diseases. Although much of the quercetin research has been performed in animals, some clinical trials have been conducted, and others are ongoing. A naturally occurring member of the flavonoid class of plant polyphenol (https://www.foundmyfi... aging antioxidant nutrition inflammation
Read more[toc position='left'] Background Zinc is an essential nutrient that participates in numerous biological processes and modulates the activity of more than 300 enzymes and 2,000 transcription factors.[ref doi='10.1136/bmj.326.7386.409'] First identified for its influence on growth and development, zinc is now understood to play critical roles in immune function, protein synthesis, wound healing, DNA synthesis, and cell division. History The importance of zinc in the human diet first became apparent in the early 1960s, after a patient with a rare syndrome presented to Dr. Ananda Prasad, a physic... nutrition interesting zinc
Read moreDr. Jed W. Fahey discusses the health benefits of isothiocyanates, including sulforaphane and moringa. ... sulforaphane nutrition brain diet nootropics inflammation heat stress autism isothiocyanates nrf2 moringa supplements
Watch nowDr. Ronald Krauss discusses the role that LDL cholesterol plays in heart disease, dyslipidemia, and atherosclerosis. ... heart disease diet aging biomarkers cholesterol inflammation
Watch now