As we age, the immune system slows, loses precision, and low-grade inflammation rises. These changes... ... aliquot inflammation immune system cold stress sauna sleep nutrition
Listen now[toc position='left'] Protein is one of nutrition's most essential and debated topics. It goes far beyond its reputation as the building block of muscle, playing a crucial role in metabolism, insulin sensitivity, and the prevention of diseases like type 2 diabetes and sarcopenia. But questions abound: How much protein is enough, and can too much, particularly from animal sources, be harmful? Protein intake, paired with resistance training, drives muscle repair and growth, enhancing athletic performance, improving metabolic health, and promoting longevity by protecting against age-related frai... protein
Read more[toc position='left'] Small vessel disease is a condition causing blood vessel dysfunction that occurs with aging and contributes to the development of cardiovascular disease, dementia, and stroke. As a consequence of the profound effects of small vessel disease on the functioning of the brain and blood-brain barrier (/topics/blood-brain-barrier), for the purposes of this article, we will focus predominantly on cerebral aspects of small vessel disease, called cerebral small vessel disease. Small vessel disease in the brain contributes to approximately 50 percent of dementia cases worldwide, in... small vessel disease brain alzheimer's vitamin d omega-3 parkinson's inflammation cardiovascular blood-brain barrier
Read more[toc position='left'] Background Zinc is an essential nutrient that participates in numerous biological processes and modulates the activity of more than 300 enzymes and 2,000 transcription factors.[ref doi='10.1136/bmj.326.7386.409'] First identified for its influence on growth and development, zinc is now understood to play critical roles in immune function, protein synthesis, wound healing, DNA synthesis, and cell division. History The importance of zinc in the human diet first became apparent in the early 1960s, after a patient with a rare syndrome presented to Dr. Ananda Prasad, a physic... nutrition interesting
Read more[toc position='left'] Epigenetic clocks are predictors of biological age based on alterations in an individual's DNA methylation profile. Methylations – biochemical processes that modify the activity of a DNA segment without changing its sequence – occur naturally and regulate gene expression to control normal growth and development. With age, the methylation state of various genes may change. These changes are quantifiable and gauge epigenetic age, which often differs from chronological age. The term "epigenetic clock" is also a collective designation referring to the natural biological mech... aging interesting epigenetics dna damage
Read more[toc position='left'] Metformin is a drug commonly used to treat type 2 diabetes. It is the fourth most widely prescribed medication in the United States, with more than 80 million prescriptions for the drug written yearly. Metformin is in a class of drugs called biguanides, which impede liver gluconeogenesis (glucose production in the liver), thereby decreasing glucose uptake in the gut and increasing overall glucose utilization by improving insulin sensitivity in skeletal muscle and fat tissue. Multiple studies demonstrate that metformin reduces fasting blood glucose levels by as much as 3.9... exercise aging diabetes
Read more[toc position='left'] Sirtuins are highly conserved enzymes that play key roles in healthspan and longevity in multiple organisms. They are linked to the regulation of a variety of metabolic processes, including the release of insulin, mobilization of lipids, response to stress, and modulation of lifespan.[ref doi='10.1016/j.tem.2013.12.001'] [ref doi='10.1016/j.bbapap.2009.11.021'] Sirtuins have been implicated in the pathophysiology of metabolic disorders such as type 2 diabetes; neurological disorders such as Parkinson’s disease; and many other conditions related to aging.[ref doi='10.3389/... aging heart disease circadian rhythm brain cancer inflammation fasting resveratrol
Read moreFOXO proteins are members of the FOX family of highly conserved transcriptional regulators. They play essential roles in human lifespan and healthy aging, influenced by environmental and genetic factors. The genetic contribution to lifespan and aging increases with time, suggesting that people who live long lives might carry so-called "protective genes." Run the longevity report to learn more about genetic polymorphisms influencing the expression of FOXO (/genetics) Background FOX proteins are named for a gene found in fruit flies that causes the insects to have forked structures on their head... aging fasting nutrition diet
Read moreDr. Satchin Panda discusses the practical aspects of implementing fasting, time-restricted eating, shift work strategies, and more. ... fasting cancer obesity metabolism diabetes circadian rhythm melatonin time-restricted eating
Watch nowTIMELINE: 00:03:22 (https://www.youtube.com/watch?v=Gm626MgpveI&t=00h03m22s) - How genetically inhibiting autophagy actually increases cellular sensitivity to death and how this was counterintuitive because autophagy was thought, at one time, as a type of activity predominantly concerned with actually initiating cell death. 00:04:44 (https://www.youtube.com/watch?v=Gm626MgpveI&t=00h04m44s) - The external signals causing autophagy. 00:05:29 (https://www.youtube.com/watch?v=Gm626MgpveI&t=00h05m29s) - The role of growth factors in transporting nutrients from the outside world into the...
Read more