[toc position='left'] The blood-brain barrier comprises various membranes that separate the central nervous system (CNS) and the peripheral circulatory system. The purpose of this barrier is to allow the passage of nutrients and cell signals from the bloodstream to nerves and supporting cells in the CNS while excluding harmful substances. Genetic predispositions, environmental exposures, and aging may weaken the integrity of this barrier, allowing endotoxins and inflammatory immune cells to infiltrate the brain, contributing to accelerated brain aging and the risk of neurodegenerative diseases... omega-3 immune system blood-brain barrier brain alzheimer's gut obesity
Read more[toc position='left'] Polyphenols comprise a group of antioxidant compounds found in a variety of plants consumed as foods and beverages. Polyphenols are one of the most common classes of bioactive compounds found in plants, along with alkaloids (e.g., berberine (https://www.foundmyfitness.com/topics/berberine)), organosulfur compounds (e.g., sulforaphane), and terpenoids (e.g., beta carotene). A growing body of evidence suggests that polyphenols have disease-fighting properties, although the evidence to support these claims varies in quality. Research has demonstrated some degree of efficacy ... polyphenol brain cancer heart disease green tea gut diet microbiome microbes
Read more[toc position='left'] Background Quercetin is a bioactive compound that exerts antioxidant and anti-inflammatory properties.[ref pmid='26393898'] Research indicates that quercetin may alleviate chronic health conditions such as hypertension, neurodegenerative disease, arthritis, and lung and kidney diseases and may be beneficial in combating aging-related diseases. Although much of the quercetin research has been performed in animals, some clinical trials have been conducted, and others are ongoing. A naturally occurring member of the flavonoid class of plant polyphenol (https://www.foundmyfi... aging antioxidant nutrition inflammation
Read more[toc position='left'] N-glycolylneuraminic acid, or Neu5Gc, is a sialic acid – a nine-carbon sugar molecule – produced by most nonhuman mammals. Sialic acids serve diverse roles, such as mediating cell-to-cell interactions, triggering cell signaling cascades, and binding to pathogens.[ref doi='10.1016/j.molmed.2008.06.002'] Humans do not produce Neu5Gc; however, trace amounts of the compound are commonly present in human urine, suggesting that Neu5Gc is obtained in the diet. Foods highest in Neu5Gc include red meat and milk. It is rarely present in fish or poultry, but eggs are rich in Neu5Ac... diet nutrition cancer inflammation
Read more[toc position='left'] Caloric restriction is the practice of long-term reduced dietary intake, typically characterized by a 20 to 50 percent decrease in caloric intake below habitual levels, without malnutrition or deprivation of essential nutrients. It involves a consistent pattern of reducing average daily caloric intake and differs from fasting and other restrictive eating patterns in that the latter regimens primarily focus on the frequency and timing of eating rather than a pattern of permanent, long-term restriction. Caloric restriction in animals Caloric restriction delays the onset of ... diet aging
Read more[toc position='left'] Nicotinamide mononucleotide (NMN) is a precursor molecule for the biosynthesis of nicotinamide adenine dinucleotide, or NAD+, a coenzyme that participates in the production of cellular energy and DNA repair. NAD+ can also be synthesized from other precursors including nicotinamide (NAM, also called niacinamide), nicotinic acid (NA), and nicotinamide riboside (NR), which are often collectively referred to as niacin (vitamin B3) or niacin equivalents.[ref doi='10.12688/f1000research.12120.1'] These precursors are not equally allocated throughout the body; rather, they exhib... aging obesity neurodegeneration exercise cancer dna damage mitochondria nad+ cardiovascular
Read more[toc position='left'] Nicotinamide adenine dinucleotide (NAD+) is a cofactor (a molecule that assists enzymes in chemical reactions) that plays an essential role in multiple physiological processes, such as energy metabolism, DNA repair, and immune activation. It is necessary for the activity of sirtuins, a class of enzymes involved in longevity, and poly-ADP-ribose polymerases (PARPs), a family of DNA-repair enzymes. Cellular NAD+ production declines with age, however, and its depletion likely drives the onset and progression of multiple age-related conditions such as metabolic dysregulation ... metabolism mitochondria aging dna damage circadian rhythm nad+
Read more[toc position='left'] Time-restricted eating is a form of daily fasting wherein the time of the day during which a person eats is limited, or compressed. People who practice time-restricted eating typically eat during an 8- to 12-hour daytime window and fast during the remaining 12 to 16 hours. Unlike intermittent fasting, which involves caloric restriction, time-restricted eating permits a person to eat as much as they want during the eating window. Time-restricted eating aligns the eating and fasting cycles to the body’s innate 24-hour circadian system.[ref doi='10.3390/ijms20081911'] Within... fasting diet metabolism sleep circadian rhythm interesting
Read more[toc position='left'] Bathing oneself in heat for the purposes of purification, cleansing, and healing is an ancient practice, dating back thousands of years and observed across many cultures. Variations of its use are seen today in the banyas of Russia, the sweat lodges of the American Indians, and, most famously, the saunas of Finland. Sauna use, sometimes referred to as "sauna bathing," is characterized by short-term passive exposure to extreme heat. This exposure elicits mild hyperthermia – an increase in the body's core temperature – that induces a thermoregulatory response involving neu... exercise inflammation sauna aging performance depression bisphenol a heat stress interesting alzheimer's
Read more[toc position='left'] Introduction [tweetbox text='"Modulation of autophagy may represent a promising therapeutic approach for extending human lifespan and healthspan."' tweet='"Modulation of autophagy may represent a promising therapeutic approach for extending human lifespan and healthspan." https://www.foundmyfitness.com/topics/autophagy'] Homeostasis, a cell's ability to maintain a constant internal environment, is essential to cell survival. It is predicated on achieving an equilibrium between the production and degradation of cellular components. One major pathway for degradation is auto... aging mitochondria autophagy nutrition exercise parkinson's cancer autoimmunity
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