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        [Podcast] Q&amp;A #80: Does Nattokinase Protect Your Heart?—What the Evidence Shows
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      Dr. Rhonda Patrick reviews the evidence for nattokinase, how oat beta-glucans may aid with PFAS excretion, and HRT for APOE4 carriers.
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        [Podcast] Q&amp;A #77: What’s the Best Time to Exercise?—Morning vs. Evening and How to Sequence Sauna and Cold
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      Dr. Rhonda Patrick discusses supplement timing, exercise timing, supplements in older adults, folic acid vs. folate, and hydrogen-rich water.
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        [Podcast] How To Use Coffee To Live Longer (Full Guide &amp; Research)
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      Dr. Rhonda Patrick discusses coffee&#39;s remarkable ability to slow biological aging, reduce DNA damage, and lower cancer risk. 
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        [Podcast] Aliquot #126: The Science of Calcium for Bone Health and Beyond
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      In this Aliquot, I&#39;ll summarize the latest research on calcium absorption, supplementation, and dietary sources, exploring...
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        [Podcast] Q&amp;A #63: How Much Sodium Do You Need—and Are Electrolyte Supplements Overhyped?
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      Dr. Rhonda Patrick discusses her supplement stack, avoiding microplastics, creatine for brain health, and mRNA vaccine autoimmunity risks.
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        [Podcast] Q&amp;A #34: Is Dark Chocolate Heart-Healthy—and What Does High Lp(a) Mean for Heart Risk?
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      Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&amp;amp;A session.
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        [Podcast] Aliquot #22: Q&amp;A Mashup - Rhonda&#39;s personal supplement routine
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      This is a special mashup episode, featuring a collection of clips on a range of topics related to supplements — including Rhonda&#39;s evolving supplement routin...
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        [Topic] NAD+
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Nicotinamide adenine dinucleotide (NAD+) is a cofactor (a molecule that assists enzymes in chemical reactions) that plays an essential role in multiple physiological processes, such as energy metabolism, DNA repair, and immune activation. It is necessary for the activity of sirtuins, a class of enzymes involved in longevity, and poly-ADP-ribose polymerases (PARPs), a family of DNA-repair enzymes. Cellular NAD+ production declines with age, however, and its depletion likely drives the onset and progression of multiple age-related conditions such as metabolic dysregulation ...
          <span class="search-tag">metabolism</span>
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          <span class="search-tag">nad+</span>
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        [Topic] Salmon roe
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      [toc position=&#39;left&#39;]
Salmon roe – sometimes referred to as &quot;salmon caviar&quot; – is the internal egg mass found in female salmon. It is served in a variety of dishes, including sushi and pasta, or as a garnish or condiment to seafood or eggs. Salmon roe is rich in protein, vitamins, astaxanthin, and the omega-3 fatty acids eicosapentaenoic acid, or EPA, and docosahexaenoic acid, or DHA. 
Omega-3 fatty acids are long-chain polyunsaturated fatty acids. They are considered essential fatty acids because the human body cannot make them. Alpha-linolenic acid, or ALA, an omega-3 fatty acid that serves a...
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        [Topic] Sirtuins
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      [toc position=&#39;left&#39;]
Sirtuins are highly conserved enzymes that play key roles in healthspan and longevity in multiple organisms. They are linked to the regulation of a variety of metabolic processes, including the release of insulin, mobilization of lipids, response to stress, and modulation of lifespan.[ref doi=&#39;10.1016/j.tem.2013.12.001&#39;] [ref doi=&#39;10.1016/j.bbapap.2009.11.021&#39;] Sirtuins have been implicated in the pathophysiology of metabolic disorders such as type 2 diabetes; neurological disorders such as Parkinson’s disease; and many other conditions related to aging.[ref doi=&#39;10.3389/...
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