Q&A #80 with Dr. Rhonda Patrick (4/4/26)
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In this Q&A, Dr. Rhonda Patrick discusses whether nicotinamide riboside is overhyped, nattokinase for heart health, nutrition for vegetarians and vegans, and APOE4-related responses to hormone replacement therapy.
Timestamps include:
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Q: Does Avmacol help reduce mercury exposure from fish?
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Q: Is nicotinamide riboside overhyped?
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Q: How do you choose the right probiotic?
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Q: Can you meet your potassium needs from food alone?
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Q: Is nattokinase worthwhile for heart health?
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Q: Does balancing zinc and copper intake reduce macular degeneration risk?
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Q: How can a vegetarian teen get adequate nutrition?
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Q: How do women carrying APOE4 respond to hormone replacement therapy?
Can nattokinase help prevent heart attacks and strokes?
Nattokinase often comes up in conversations about heart health, especially because of its potential effects on blood clotting and atherosclerosis. At first glance, the mechanism sounds compelling. But when you look closely at the human evidence, the picture becomes much more complex and nuanced. So what does the research actually say, and how much confidence should we place in it?
What is nattokinase and why is it considered promising?
Nattokinase is an enzyme produced by the bacterium Bacillus subtilis var. natto during fermentation. It is naturally present in natto, a traditional Japanese food made from fermented soybeans, and can also be produced via industrial fermentation for use in supplements. What makes this enzyme particularly interesting is its fibrinolytic activity, meaning it helps break down fibrin, a key protein involved in blood clot formation. This activity is quantified in fibrinolytic units (FU), which are also used to standardize dosing in supplements.
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Beginning of Q&A
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Q: Which sardine brand do you prefer?
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Q: How do steel-cut oats, oat bran, and oat milk compare for beta-glucan content? 1
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Q: Are you still taking PQQ?
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Q: Have you noticed any benefits from urolithin A?
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Q: Is nutritional yeast a meaningful source of beta-glucans?
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Q: How much vitamin K do you take, and would that change with age?
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Q: Is decaf coffee safe during pregnancy?
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Q: Should vitamin K1 and K2 intake be adjusted with age?
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Q: Can you meet your potassium needs from food alone? 1
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Q: Is there evidence for limiting vitamin D intake to 2000 IU per day?
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Q: Which creatine brand do you use?
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Q: What is your opinion on methylene blue?
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Q: Are refrigerator water filters adequate?
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Q: How much omega-3 should APOE4 carriers take?
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Q: What omega-3 intake is needed to reach an 8% Omega-3 Index? 1
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Q: Do you add minerals back to your reverse osmosis water?
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Q: Why did you switch omega-3 supplement brands?
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Q: Is the Waterdrop countertop reverse osmosis filter effective?
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Watch previously recorded Q&As with Dr. Rhonda Patrick
Q&A #81 with Dr. Rhonda Patrick (5/2/26)
Dr. Rhonda Patrick discusses beta-glucan fiber for PFAS reduction, creatine and caffeine, urolithin A, exogenous ketones, IVF supplements, Botox, and sauna.
Q&A #79 with Dr. Rhonda Patrick (3/14/26)
Dr. Rhonda Patrick discusses nicotinamide riboside, biomarkers, belly fat loss, sex-specific health, curcumin & ashwagandha safety.
Q&A #78 with Dr. Rhonda Patrick (2/07/26)
Dr. Rhonda Patrick discusses child nutrition, osteoporosis, cholesterol-lowering supplements, her skincare routine, and fasting versus prioritizing protein.
Q&A #77 with Dr. Rhonda Patrick (1/17/26)
Dr. Rhonda Patrick discusses supplement timing, exercise timing, supplements in older adults, folic acid vs. folate, and hydrogen-rich water.
Q&A #76 with Dr. Rhonda Patrick (12/06/25)
Dr. Rhonda Patrick discusses protein needs, choline in pregnancy, urolithin A, melatonin's benefits and risks, and creatine's effects on liver health.