Dr. Rhonda Patrick and Dr. Steve Horvath discuss how epigenetic clocks measure biological age and which proven interventions actually slow or reverse aging. ... epigenetics telomeres genetics stem cells omega-3 dna damage biomarkers aging vitamin d senescence multivitamin
Watch now[toc] Urolithin A is a postbiotic—a compound our gut microbes can form from ellagitannins and ellagic acid, polyphenols found in foods such as pomegranates, strawberries, and walnuts. Because production depends on the presence of specific gut microbes, people fall into distinct "metabotypes" (A = good UA producers, B = partial producers, 0 = non-producers), and only a minority make large amounts from diet alone. Therefore, purified UA supplements bypass that microbiome variability.[ref doi='10.3389/fmicb.2017.01521'] Mechanistically UA is best known as an inducer of mitophagy—the selective au... immune system gut aging prebiotics urolithin a microbiome
Read more[toc position='left] Sodium plays a crucial role in human physiology, yet its consumption remains a topic of ongoing debate in health and nutrition science. While it is essential for maintaining fluid balance, nerve function, and muscle contractions, excessive intake has been linked to various adverse health effects, particularly cardiovascular disease and hypertension. The complexity of sodium's role in health arises from individual variability in salt sensitivity, lifestyle factors, and dietary habits. Sodium and Blood Pressure One of the most well-established relationships in nutrition scie... nutrition blood pressure cardiovascular obesity micronutrients salt
Read more[toc position='left'] Introduction Omega-3 fatty acids are polyunsaturated fats that play critical roles in human health, participating in a wide range of biochemical pathways and processes and modulating the expression of genes throughout the lifespan. Omega-3 fatty acids include plant-derived alpha-linolenic acid (ALA) and marine-derived eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), among others. A growing body of evidence indicates that omega-3 fatty acids may prevent or ameliorate symptoms associated with chronic health conditions such as cardiovascular disease,[ref doi='10.3... cancer depression mortality omega-3 nutrition brain diet aging immune system mental health development intelligence
Read more[toc position='left'] Toll-like receptors are a family of pattern recognition receptors expressed on the surface of immune and other cells. Toll-like receptors are the principal inducers of innate immunity[ref doi='10.1186/cc1471'], activating transcription factors such as NF-kB that increase the expression of inflammatory cytokines. Among toll-like receptors, TLR4 is notable for recognizing lipopolysaccharide (LPS), a structure found on the outer membranes of Gram-negative bacteria. This overview will predominantly focus on TLR4 and its involvement in human health, disease, and behavior. Toll... toll-like receptors gut aging microbiome inflammation immune system intestinal permeability omega-3 endotoxemia
Read more[toc position='left'] Brain-derived neurotrophic factor, or BDNF, is a growth factor relevant to aging, brain function, behavior, metabolism, energy expenditure, and satiety. BDNF serves as a cell signaling protein, plays vital roles in numerous signaling pathways associated with a variety of disorders ranging from depression, (https://www.foundmyfitness.com/topics/depression) schizophrenia, and addiction to obesity and diabetes, and may serve as a hormone. It is perhaps best known for its influence on the formation, growth, survival, and development of neurons and for its role in mediating th... exercise omega-3 meditation brain alzheimer's parkinson's fasting memory interesting
Read moreIn this clip, Dr. Rhonda Patrick describes the many open questions that remain regarding the interaction between metformin and exercise at the molecular level. ... exercise mitochondria metformin
Watch nowIn this clip, Dr. Rhonda Patrick gives her thoughts on whether healthy, active adults should take metformin. ... aging exercise diabetes metformin
Watch nowScience on refined sugar: mortality, aging, brain function, memory, neuroinflammation, cancer, sex hormones, addiction & more. ... sugar nutrition brain cancer diet aging memory addiction
Listen nowDr. Satchin Panda discusses the roles that fasting, time-restricted eating, and circadian rhythms play in human health. ... fasting obesity podcast circadian rhythm melatonin video fatty liver time-restricted eating
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