Sauna use, depression and addiction — the dynorphin thermoregulatory connection | Roland Griffiths
The body produces an opioid called dynorphin, which is generally responsible for dysphoria, a profound sense of unease or dissatisfaction. The binding of dynorphin to kappa-opioid receptors triggers cellular events that promote pain and distress. Sauna use promotes dynorphin release, which may be responsible for the general sense of discomfort experienced during heat exposure. Interestingly, in a biological feedback response that occurs after dynorphin binds to the kappa-opioid receptor, the brain produces more mu-opioid receptors, sensitizing them to endorphin and future endorphin exposure, a process known as the Salvinorin A pathway. As such, sauna use has potential as a means to treat depression and opioid addiction. In this clip, Dr. Rhonda Patrick describes how sauna use activates the Salvinorin A pathway, potentially ameliorating symptoms of depression and opioid addiction.
Member support keeps us strong.
If you enjoy the fruits of , you can participate in helping us to keep improving it. Creating a pay-what-you-can subscription does just that! Plus, we throw in occasional member perks and, more importantly, churn out the best possible content without concerning ourselves with the wishes of any dark overlords.
Our website is 100% supported by people like you through this pay-what-you-can mechanism.
Fundamentals$15 / month
Loyal Fan$25 / month
Super Fan$50 / month
Power Supporter$125 / month
Heroic Supporter$250 / month