Late-night eating and melatonin may impair insulin response
The production of melatonin begins to increase 2-3 hours before our normative bedtime, which may be a signal to the pancreas to begin suppressing the production of insulin.
Sleep loss impairs glucose regulation (but exercise helps)
Several studies have established causation showing that sleep duration is a major determinant of insulin sensitivity.
Dr. Matthew Walker on Sleep for Enhancing Learning, Creativity, Immunity, and Glymphatic System
Matthew Walker, Ph.D., is a professor of neuroscience and psychology at the University of California, Berkeley, and serves as the Director of the Center for Human Sleep Science. Formerly, Dr. Walker served as a professor of psychiatry at the Harvard Medical School. He is the author of the New York Times best-selling book Why We Sleep: Unlocking the Power of Sleep and Dreams.
Fasting Q&A with Dr. Rhonda Patrick and Mike Maser
This episode features a Q&A session on fasting-related topics with Dr. Rhonda Patrick and Mike Maser of Zero Fasting Tracker.
Joe Rogan Experience #1178 - Dr. Rhonda Patrick
Dr. Rhonda Patrick makes her eighth appearance on the Joe Rogan Experience.
Dr. Dale Bredesen on Preventing and Reversing Alzheimer's Disease
Dr. Bredesen’s is known for his work in translating his scientific research into effective treatments for Alzheimer’s disease. He is the author of the book The End of Alzheimer's and the ReCODE protocol – reversal of cognitive decline – a protocol that offers a new approach to treatment that has reversed symptoms in patients with mild cognitive impairment and Alzheimer’s disease.
Salmon Roe Stacks Recipe
This short recipe video shows a fun, tasty way to eat salmon roe. Salmon roe is rich in the omega-3 fatty acid, docosahexaenoic acid, in its phospholipid form.
Dr. Valter Longo on Resetting Autoimmunity and Rejuvenating Systems with Prolonged Fasting & the FMD
Round 2 with Dr. Valter Longo. Valter Longo, PhD, is a biochemist and professor of gerontology and biological sciences at the University of Southern California (USC). He directs the USC Longevity Institute as well as the Oncology and Longevity Program at the Institute of Molecular Oncology Foundation in Milan, Italy.
Dr. Charles Raison on Depression, the Immune-Brain Interface & Whole-Body Hyperthermia
Dr. Charles Raison’s research focuses on inflammation and the development of depression in response to illness and stress. He also examines the physical and behavioral effects of compassion training on the brain, inflammatory processes, and behavior as well as the effect of heat stress as a potentially therapeutic intervention major depressive disorder.
Joe Rogan Experience #1054 - Dr. Rhonda Patrick
Dr. Rhonda Patrick makes her seventh appearance on the Joe Rogan Experience.
Dr. Eric Verdin on Ketogenic Diet Longevity, Beta-Hydroxybutyrate, HDAC Inhibitors & NAD+
Eric M. Verdin, M.D. is the fifth president and chief executive officer of the Buck Institute for Research on Aging and is a professor of Medicine at UCSF.
Does Saturated Fat Cause Heart Disease?
Several associative studies that have found a link between saturated fat and heart disease... should we be concerned?
How To Increase Sulforaphane in Broccoli Sprouts by ~3.5-fold
This is a video on how to plausibly increase the sulforaphane created from the glucoraphanin in your broccoli sprouts by up to 3.5-fold.
Nutrigenomics, Epigenetics, and Stress Tolerance (IHMC Talk #1)
Our genes influence the way we absorb and metabolize micronutrients. Nutrigenomics looks at the influence genetic variation has over micronutrient absorption/metabolism and the biological consequences of this dynamic relationship.
Low-Carb Lemon Tart Dessert (High Citrate & Choline)
In this video Dr. Rhonda Patrick shares her recipe for low-carb lemon tart and demonstrates how to make it.
Sleep, Daylight Anchoring, and Effects on Memory & Obesity with Dan Pardi
Dan Pardi is a Ph.D candidate that researches sleep neurobiology at Stanford and University of Leiden. He is also co-founder of Dan’s Plan, an online wellness and technology company.
"Hacking Your Genes" at SF Nerd Nite
Dr. Rhonda Patrick talks about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.
Dr. Satchin Panda on Practical Implementation of Time-Restricted Eating & Shift Work Strategies
It's time to abandon ad libitum! This is an almost two-hour round 2 episode with Dr. Satchin Panda focused on practical implementation of time-restricted eating, various circadian insights, and much more.
Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation
Dr. Guido Kroemer is a professor at the University of Paris Descartes and an expert in immunology, cancer biology, aging, and autophagy.
Dr. Jari Laukkanen on Sauna Use for the Prevention of Cardiovascular & Alzheimer’s Disease
Dr. Laukkanen has been conducting long-term trials looking at the health effects of sauna use in a population of over 2,000 middle-aged men in Finland. The results? Massive reductions in mortality and memory disease in a dose-dependent fashion at 20-year follow-up.
Judith Campisi, Ph.D., on Cellular Senescence, Mitochondrial Dysfunction, Cancer & Aging
Dr. Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging, a co-editor in chief of the _Aging Journal_ and an expert on the role of cellular senescence in the aging process and development of cancer.
Gordon Lithgow, Ph.D. on Protein Aggregation, Iron Overload & the Search for Longevity Compounds
Dr. Gordon Lithgow is a professor of gerontology at the Buck Institute for Research on Aging. The topic of conversation in this episode is especially focused on Dr. Lithgow's work with C. elegans, which a tiny nematode worm he uses to interrogate questions involving the aging process and lifespan extension.
Refined Sugar and Its Effects on Mortality, the Brain, Cancer, Hormones, & More
What does the science say about the consumption of refined sugar? This episode covers mortality and aging, brain function, memory, neuroinflammation, development of cancer, sex hormones, addiction, & more.
The Underlying Mechanisms of Depression
Systemic inflammation is an important mechanism that research shows may have a very interesting relationship with depression.
Jed Fahey, ScD, on Isothiocyanates, the Nrf2 Pathway, Moringa, & Sulforaphane Supplementation
Dr. Jed W. Fahey is a nutritional biochemist with deep experience researching isothiocyanates like sulforaphane.
Roland Griffiths, Ph.D. on Psilocybin, Psychedelic Therapies & Mystical Experiences
Dr. Roland Griffiths is a clinical pharmacologist at Johns Hopkins and one of the world's foremost researchers on the psychedelic compound psilocybin.
Joe Rogan Experience #901 - Dr. Rhonda Patrick
Dr. Rhonda Patrick makes her fifth appearance on the Joe Rogan Experience.
Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease, & More
This podcast is about one of the most important biological pathways you could possibly take the time to learn about: the NRF2 pathway.
Valter Longo, Ph.D. on the Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis
Dr. Rhonda Patrick speaks with Dr. Valter Longo, a professor of gerontology and biological sciences and director of the longevity institute at the University of Southern California.
Ruth Patterson, Ph.D. on Time-Restricted Eating in Humans & Breast Cancer Prevention
This episode features Dr. Ruth Patterson, a professor in the UC San Diego Department of Family Medicine and Public Health as well as Associate Director of Population Sciences and leader of the Cancer Prevention program at Moores Cancer Center at UC San Diego Health.
Satchin Panda, Ph.D. on Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass & Heart Health
Dr. Rhonda Patrick speaks with Dr. Satchin Panda, a professor at the Salk Institute for Biological Studies in La Jolla California. Satchin's work deals specifically with the timing of food and it's relationship with our biological clocks, which are governed by a circadian rhythm.
Smoothie #2: Prebiotics, Phytochemicals, "Anti-Nutrients" & Hydrolyzed Collagen
A modest change on the "micronutrient smoothie" that also talks about the beneficial compounds that don't qualify as micronutrients.
Ray Cronise on Cold Thermogenesis, Intermittent Fasting, Weight Loss & Healthspan
Dr. Rhonda Patrick speaks with Ray Cronise, a former NASA material scientist and co-founder of zero gravity, a company that offers weightless parabolic flights to consumers and researchers.
Dominic D'Agostino, Ph.D. on Modified Atkins Diet, Ketosis, Supplemental Ketones and More
This podcast is with Dr. Dominic D'Agostino, an assistant professor at the University of South Florida in Tampa and all around expert on ketosis.
Peter Attia, M.D. on Macronutrient Thresholds for Longevity and Performance, Cancer & More
Dr. Peter Attia is the founder of Attia Medical, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity and optimal performance.
How Cryotherapy Affects the Brain, the Immune System, Metabolism, and Athletic Performance
Dr. Rhonda Patrick explains how cold shock may be a type of hormesis – a stressor that, in the right dose, is enough to shock the body and kick off adaptive processes and response mechanisms that exceed what was needed to counter the initial stimuli and, ultimately, promote resilience.
Rich Roll on Self-Transformation, Environmental Impact of Food, and the Plant-Based Diet
This podcast features Rich Roll. Rich is an author, a podcaster, as well as founder and first person to complete the EPIC5 Challenge.
Dr. Darya and Kevin Rose Talk Meditation Retreats, Diet, Seasonal Eating, and More
Dr. Darya Rose & husband Kevin Rose join Rhonda for a chat about multi-day silent meditation retreats, Kevin's experiments with a ketogenic diet, and some ideas and other projects he's working.
Dr. Pierre Capel on the Power of the Mind & the Science of Wim Hof
Dr. Rhonda Patrick interviews Dr. Pierre Capel, professor emeritus in experimental immunology at the Utrecht University in the Netherlands where he researched a wide range of topics from genetic modification to cancer immunotherapy.
Wim Hof (the Iceman) on Defeating Extreme Cold & Attenuating the Immune Response
Dr. Rhonda Patrick interviews Wim Hof and discusses the 2014 study on his technique with him.
PRESENTATION: Rhonda Speaks at the Orthomolecular Congress in Bussum, Netherlands
Dr. Rhonda Patrick delivers the keynote lecture at the Orthomolecular Medicine Congress in Bussum, Netherlands (MBOG Congres 2015). Discussion: prevalency of micronutrient inadequacy & Dr. Bruce Ames' triage theory.
Sauna Use and Building Resilience to Stress with Dr. Rhonda Patrick
This episode is a presentation Dr. Rhonda Patrick delivered at the Biohacker Summit in Helsinki, Finland in 2016.
How The Gut Microbiota Affects Our Health with Dr. Erica & Dr. Justin Sonnenburg
Drs. Erica and Justin Sonnenburg both research the interaction between diet and the trillions of bacteria in the gut.
Dr. Ronald Krauss on LDL Cholesterol, Particle Size, Heart Disease & Atherogenic Dyslipidemia
Ronald Krauss, M.D., is the director of atherosclerosis research at Children’s Hospital Oakland Research Institute and an adjunct professor at UCSF and UC Berkeley.
Buffering the Negative Effects of Chronic Stress with Meditation
In this podcast, Rhonda discusses some of the mechanisms by which chronic stress (and rumination) affect the brain and brain aging, the gut and inflammation, the immune system, and biological aging through acceleration of telomere shortening. She talks about how meditation can buffer these negative effects of stress and improve cognitive performance, brain aging, and biological aging in general.
Dr. Aubrey de Grey and Dr. Rhonda Patrick Talk Aging
Dr. Aubrey de Grey is a biomedical gerontologist and the founder of the SENS research foundation which aims to find technologies that can repair the various types of damage that occur during the aging process.
Tim Ferriss on Biomarkers, Ketosis, Microbiome, and Lyme Disease
Tim Ferriss, notorious self-experimenter, angel investor, startup advisor, NY Times bestselling author (3x), and much more.
Dr. Bruce Ames Talks CHORI-Bar Weight Loss
Dr. Rhonda Patrick speaks with Dr. Bruce Ames, about a micronutrient- and fiber-dense nutrition bar (referred to as the CHORI bar) that was developed in the Ames laboratory.
Jim Kean Talks Biomarkers, Building a Spectator Sport
Jim Kean is the CEO of National Pro Grid League (NPGL) and founder of WellnessFX.
How Sauna Use May Boost Longevity
In this video, Dr. Rhonda Patrick summarizes a recent study that found that frequency of sauna use was associated with increased decreased risk of death. Using the sauna 2-3 times per week was associated with 24% lower all-cause mortality and 4-7 times per week decreased all-cause mortality by 40%.
Personalize Your Nutrition Based On Genetics
This video breaks down, point-by-point what gene polymorphisms you might look at, and how they relate to very specific micronutrients.
DEBUNKED: 2/3rds of Cancer "Just Bad Luck"
Is cancer just bad luck? To some degree, yes... but there's also a very, very large environmental and lifestyle component.
Bruce Ames on Triage Theory, Longevity Vitamins & Micronutrients
Dr. Bruce Ames discusses his triage theory, which he proposes that the body has developed a rationing response to shortages of micronutrients (vitamins and minerals) throughout evolution.
Dr. Frans Kuypers on Placenta as a Source of Bankable Stem Cells
Dr. Frans Kuypers and his lab pioneered a technique that helps retrieve pluripotent stem cells from placental tissue, which is routinely needless discarded worldwide.
George Brooks, PhD, on Lactate Shuttle Theory, Relevance for Traumatic Brain Injury, & More
Contrary to commonly held beliefs, lactate is not the cause of muscle fatigue. Rather, it's an essential source of energy itself, greedily metabolized with a greater degree of preference than many other sources of energy, including glucose. Recent research suggests that the lactate metabolic pathway plays a critical role in the context of recovery from traumatic brain injury.
Joe Rogan Experience #568 - Dr. Rhonda Patrick
Dr. Rhonda Patrick makes her third appearance on the Joe Rogan Experience.
The Phospholipid Brain-DHA Advantage
There may be something special about sources of omega-3 that are richer in the phosphatidylcholine form of DHA.
Do Antioxidants Cause Cancer?
Dr. Rhonda Patrick explains what antioxidants are, why they are important, and how they prevent DNA damage, a well-known cancer initiator.
Dr. Terry Wahls Discusses Her Multiple Sclerosis Protocol
Dr. Terry Wahls discusses the protocol she used to reverse her secondary-progressive multiple sclerosis.
3 Mechanisms for Magnesium Deficiency
Decreased consumption of chlorophyll containing vegetables, decreased absorption, and increased excretion is largely the primary reasons why apprximately 45% of US population is deficient in magnesium.
Maximizing Your Mitochondria with Magnesium
Dr. Patrick describes how magnesium, an essential mineral that ~56% of the US population is deficient in, can help you maximize your mitochondria to increase oxidative capacity and, potentially, enhance exercise performance.
Joe Rogan Experience #502 - Dr. Rhonda Patrick
Dr. Rhonda Patrick makes her second appearance on the Joe Rogan Experience.
Hyperthermic Conditioning for Hypertrophy, Endurance, and Neurogenesis
Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass.
Joe Rogan Experience #459 - Dr. Rhonda Patrick
Dr. Rhonda Patrick makes her first appearance on the Joe Rogan Experience.
Rebuttal to Anti-Vitamin Editorial: "Enough is Enough"
In this podcast, we discuss and critically analyze a recent headline-grabbing editorial that was published in the Annals of Internal Medicine that reviewed three studies on the topic of multivitamins and chronic disease prevention. We analyze the important shortcomings of the studies and talk about the mechanism.