The production of melatonin begins to increase 2-3 hours before our normative bedtime, which may be a signal to the pancreas to begin suppressing the production of insulin.

Several studies have established causation showing that sleep duration is a major determinant of insulin sensitivity.

Matthew Walker, Ph.D., is a professor of neuroscience and psychology at the University of California, Berkeley, and serves as the Director of the Center for Human Sleep Science. Formerly, Dr. Walker served as a professor of psychiatry at the Harvard Medical School. He is the author of the New York Times best-selling book Why We Sleep: Unlocking the Power of Sleep and Dreams.

This episode features a Q&A session on fasting-related topics with Dr. Rhonda Patrick and Mike Maser of Zero Fasting Tracker.

Dr. Rhonda Patrick makes her eighth appearance on the Joe Rogan Experience.

Dr. Bredesen’s is known for his work in translating his scientific research into effective treatments for Alzheimer’s disease. He is the author of the book The End of Alzheimer's and the ReCODE protocol – reversal of cognitive decline – a protocol that offers a new approach to treatment that has reversed symptoms in patients with mild cognitive impairment and Alzheimer’s disease.

This short recipe video shows a fun, tasty way to eat salmon roe. Salmon roe is rich in the omega-3 fatty acid, docosahexaenoic acid, in its phospholipid form.

Round 2 with Dr. Valter Longo. Valter Longo, PhD, is a biochemist and professor of gerontology and biological sciences at the University of Southern California (USC). He directs the USC Longevity Institute as well as the Oncology and Longevity Program at the Institute of Molecular Oncology Foundation in Milan, Italy.

Dr. Charles Raison’s research focuses on inflammation and the development of depression in response to illness and stress. He also examines the physical and behavioral effects of compassion training on the brain, inflammatory processes, and behavior as well as the effect of heat stress as a potentially therapeutic intervention major depressive disorder.

Dr. Rhonda Patrick makes her seventh appearance on the Joe Rogan Experience.

Eric M. Verdin, M.D. is the fifth president and chief executive officer of the Buck Institute for Research on Aging and is a professor of Medicine at UCSF.

Several associative studies that have found a link between saturated fat and heart disease... should we be concerned?

This is a video on how to plausibly increase the sulforaphane created from the glucoraphanin in your broccoli sprouts by up to 3.5-fold.

Our genes influence the way we absorb and metabolize micronutrients. Nutrigenomics looks at the influence genetic variation has over micronutrient absorption/metabolism and the biological consequences of this dynamic relationship.

In this video Dr. Rhonda Patrick shares her recipe for low-carb lemon tart and demonstrates how to make it.

Dan Pardi is a Ph.D candidate that researches sleep neurobiology at Stanford and University of Leiden. He is also co-founder of Dan’s Plan, an online wellness and technology company.

Dr. Rhonda Patrick talks about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.

It's time to abandon ad libitum! This is an almost two-hour round 2 episode with Dr. Satchin Panda focused on practical implementation of time-restricted eating, various circadian insights, and much more.

Dr. Guido Kroemer is a professor at the University of Paris Descartes and an expert in immunology, cancer biology, aging, and autophagy.

Dr. Laukkanen has been conducting long-term trials looking at the health effects of sauna use in a population of over 2,000 middle-aged men in Finland. The results? Massive reductions in mortality and memory disease in a dose-dependent fashion at 20-year follow-up.

Dr. Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging, a co-editor in chief of the _Aging Journal_ and an expert on the role of cellular senescence in the aging process and development of cancer.

Dr. Gordon Lithgow is a professor of gerontology at the Buck Institute for Research on Aging. The topic of conversation in this episode is especially focused on Dr. Lithgow's work with C. elegans, which a tiny nematode worm he uses to interrogate questions involving the aging process and lifespan extension.

What does the science say about the consumption of refined sugar? This episode covers mortality and aging, brain function, memory, neuroinflammation, development of cancer, sex hormones, addiction, & more.

Systemic inflammation is an important mechanism that research shows may have a very interesting relationship with depression.

Dr. Jed W. Fahey is a nutritional biochemist with deep experience researching isothiocyanates like sulforaphane.

Dr. Roland Griffiths is a clinical pharmacologist at Johns Hopkins and one of the world's foremost researchers on the psychedelic compound psilocybin.

Dr. Rhonda Patrick makes her fifth appearance on the Joe Rogan Experience.

This podcast is about one of the most important biological pathways you could possibly take the time to learn about: the NRF2 pathway.

Dr. Rhonda Patrick speaks with Dr. Valter Longo, a professor of gerontology and biological sciences and director of the longevity institute at the University of Southern California.

This episode features Dr. Ruth Patterson, a professor in the UC San Diego Department of Family Medicine and Public Health as well as Associate Director of Population Sciences and leader of the Cancer Prevention program at Moores Cancer Center at UC San Diego Health.

Dr. Rhonda Patrick speaks with Dr. Satchin Panda, a professor at the Salk Institute for Biological Studies in La Jolla California. Satchin's work deals specifically with the timing of food and it's relationship with our biological clocks, which are governed by a circadian rhythm.

A modest change on the "micronutrient smoothie" that also talks about the beneficial compounds that don't qualify as micronutrients.

Dr. Rhonda Patrick speaks with Ray Cronise, a former NASA material scientist and co-founder of zero gravity, a company that offers weightless parabolic flights to consumers and researchers.

This podcast is with Dr. Dominic D'Agostino, an assistant professor at the University of South Florida in Tampa and all around expert on ketosis.

Dr. Peter Attia is the founder of Attia Medical, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity and optimal performance.

Dr. Rhonda Patrick explains how cold shock may be a type of hormesis – a stressor that, in the right dose, is enough to shock the body and kick off adaptive processes and response mechanisms that exceed what was needed to counter the initial stimuli and, ultimately, promote resilience.

This podcast features Rich Roll. Rich is an author, a podcaster, as well as founder and first person to complete the EPIC5 Challenge.

Dr. Darya Rose & husband Kevin Rose join Rhonda for a chat about multi-day silent meditation retreats, Kevin's experiments with a ketogenic diet, and some ideas and other projects he's working.

Dr. Rhonda Patrick interviews Dr. Pierre Capel, professor emeritus in experimental immunology at the Utrecht University in the Netherlands where he researched a wide range of topics from genetic modification to cancer immunotherapy.

Dr. Rhonda Patrick interviews Wim Hof and discusses the 2014 study on his technique with him.

Dr. Rhonda Patrick delivers the keynote lecture at the Orthomolecular Medicine Congress in Bussum, Netherlands (MBOG Congres 2015). Discussion: prevalency of micronutrient inadequacy & Dr. Bruce Ames' triage theory.

This episode is a presentation Dr. Rhonda Patrick delivered at the Biohacker Summit in Helsinki, Finland in 2016.

Drs. Erica and Justin Sonnenburg both research the interaction between diet and the trillions of bacteria in the gut.

Ronald Krauss, M.D., is the director of atherosclerosis research at Children’s Hospital Oakland Research Institute and an adjunct professor at UCSF and UC Berkeley.

In this podcast, Rhonda discusses some of the mechanisms by which chronic stress (and rumination) affect the brain and brain aging, the gut and inflammation, the immune system, and biological aging through acceleration of telomere shortening. She talks about how meditation can buffer these negative effects of stress and improve cognitive performance, brain aging, and biological aging in general.

Dr. Aubrey de Grey is a biomedical gerontologist and the founder of the SENS research foundation which aims to find technologies that can repair the various types of damage that occur during the aging process.

Tim Ferriss, notorious self-experimenter, angel investor, startup advisor, NY Times bestselling author (3x), and much more.

Dr. Rhonda Patrick speaks with Dr. Bruce Ames, about a micronutrient- and fiber-dense nutrition bar (referred to as the CHORI bar) that was developed in the Ames laboratory.

Jim Kean is the CEO of National Pro Grid League (NPGL) and founder of WellnessFX.

In this video, Dr. Rhonda Patrick summarizes a recent study that found that frequency of sauna use was associated with increased decreased risk of death. Using the sauna 2-3 times per week was associated with 24% lower all-cause mortality and 4-7 times per week decreased all-cause mortality by 40%.

This video breaks down, point-by-point what gene polymorphisms you might look at, and how they relate to very specific micronutrients.

Is cancer just bad luck? To some degree, yes... but there's also a very, very large environmental and lifestyle component.

Dr. Bruce Ames discusses his triage theory, which he proposes that the body has developed a rationing response to shortages of micronutrients (vitamins and minerals) throughout evolution.

Dr. Frans Kuypers and his lab pioneered a technique that helps retrieve pluripotent stem cells from placental tissue, which is routinely needless discarded worldwide.

Contrary to commonly held beliefs, lactate is not the cause of muscle fatigue. Rather, it's an essential source of energy itself, greedily metabolized with a greater degree of preference than many other sources of energy, including glucose. Recent research suggests that the lactate metabolic pathway plays a critical role in the context of recovery from traumatic brain injury.

Dr. Rhonda Patrick makes her third appearance on the Joe Rogan Experience.

There may be something special about sources of omega-3 that are richer in the phosphatidylcholine form of DHA.

Dr. Rhonda Patrick explains what antioxidants are, why they are important, and how they prevent DNA damage, a well-known cancer initiator.

Dr. Terry Wahls discusses the protocol she used to reverse her secondary-progressive multiple sclerosis.

Decreased consumption of chlorophyll containing vegetables, decreased absorption, and increased excretion is largely the primary reasons why apprximately 45% of US population is deficient in magnesium.

Dr. Patrick describes how magnesium, an essential mineral that ~56% of the US population is deficient in, can help you maximize your mitochondria to increase oxidative capacity and, potentially, enhance exercise performance.

Dr. Rhonda Patrick makes her second appearance on the Joe Rogan Experience.

Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass.

Dr. Rhonda Patrick makes her first appearance on the Joe Rogan Experience.

In this podcast, we discuss and critically analyze a recent headline-grabbing editorial that was published in the Annals of Internal Medicine that reviewed three studies on the topic of multivitamins and chronic disease prevention. We analyze the important shortcomings of the studies and talk about the mechanism.