The following 17 clips are taken from the episode "Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks." The FoundMyFitness Clips channel surfaces meaningful bite-sized moments primarily from the FoundMyFitness interview series. Subscribe for several times-per-week clip updates.
GrimAge, an epigenetic time-to-death prediction for anti-aging trials | Steve Horvath
The GrimAge clock (named for the Grim Reaper) predicts lifespan and healthspan in units of years and tests whether potential lifestyle interventions may slow or reverse biological aging. Click To Tweet
Weight loss and reversing metabolic syndrome may slow epigenetic aging | Steve Horvath
In this clip, Dr. Steve Horvath describes research suggesting that caloric restriction, especially when it is reversing obesity or metabolic syndrome, may slow epigenetic aging. Click To Tweet
Chronic inflammation accelerates epigenetic aging: transposon and HIV virus-associated aging
Some epigenetic clock evidence reinforces the idea that accelerated aging may be a consequence of chronic inflammation. Click To Tweet
Vitamin D and omega-3 may slow epigenetic aging | Steve Horvath
Emerging evidence now suggests that supplemental omega-3 fatty acids or vitamin D slow epigenetic aging. Click To Tweet
Heredity plays a key role in epigenetic aging speed | Steve Horvath
Evidence indicates that the heritability of epigenetic aging is about 40 percent. This is seen in supercentenarians and their offspring, who tend to age slower than their younger counterparts. Click To Tweet
Epigenetic age vs. clinical biomarkers as tools for understanding aging | Steve Horvath
Sometimes a person's clinical biomarkers doesn't accurately reflect how well they are aging, but epigenetic clocks may give a more reliable insight into their aging. Click To Tweet
Horvath epigenetic aging clocks measure two types of age: biological aging vs. chronological aging
In this clip, Dr. Steve Horvath explains the differences between chronological age and biological age. Click To Tweet
Melted Test Tubes! DNA methylation, a "forensically stable" measure of aging | Steve Horvath
The stability of methylation patterns on DNA samples means the data can be trusted more in the lab when investigating anti-aging interventions. Click To Tweet
How epigenetic predictions align with onset of cancer, Parkinson's and Alzheimer's | Steve Horvath
A person's epigenetic age correlates with their risk for developing major diseases of aging like cancer, Alzheimer's disease, and Parkinson's. Click To Tweet
How lifestyle factors can slow or accelerate epigenetic aging | Steve Horvath
Conventional health advice, such as healthy eating, physical activity, and education level are linked with slowed epigenetic aging, albeit weakly, and obesity, sleep deprivation, and smoking are linked with accelerated epigenetic aging. Click To Tweet
Can young stem cells reverse epigenetic age? | Steve Horvath
Scientists have observed that the epigenetic clock of transplanted cells and their descendant lineages synchronize with the donor rather than the recipient, a fascinating phenomenon that offers promise for the idea of rejuvenation in humans. Click To Tweet
How changes in cellular identity and stem cell differentiation affect epigenetic age
As techniques are developed to differentiate and transdifferentiate cells from one cell type, such as a fibroblast, into another, such as a neuron, interesting patterns of effects on epigenetic age are revealed. Click To Tweet
Methyltransferases and TET, a demethylation enzyme, alter epigenetic age | Steve Horvath
Methylation and demethylation are critical processes in development and interfering with the enzymes that carry out these two opposing processes can play critical roles in epigenetic age. Click To Tweet
Does the epigenetic clock play a causal role in aging? | Steve Horvath
In this clip, Dr. Steve Horvath discusses whether epigenetic clocks play causal roles in aging. Click To Tweet
GrimAge vs. Telomere length: a better biomarker for aging | Steve Horvath
The DNAm GrimAge epigenetic clock may be a more reliable predictor of healthspan and lifespan than traditional hallmarks of aging like telomeres. Click To Tweet
Can senolytic drugs improve epigenetic aging? | Steve Horvath
In this clip, Dr. Steve Horvath discusses how epigenetic aging differs from senescence-mediated aging. Click To Tweet
"Interrupted" reprogramming with Yamanaka factors reverse epigenetic age | Steve Horvath
A study using a mouse model of premature aging showed that short-term expression of four special factors which reverse epigenetic age ameliorated cellular and physiological hallmarks of aging and prolonged lifespan. Click To Tweet
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