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This might be an important detail for people using sulforaphane to boost NRF2 expression. The benefits of NRF2 expression are pretty well known, but from this article it seems like having NRF2 strongly activated all the time might have some downside effects in the long-term. I used to take sulforaphane every day, but now I’m thinking about spacing my broccoli sprouts out a little bit, with the goal of letting NRF2 expression cycle up and down over time, hopefully deriving the benefits without incurring tissue damage. Have I misunderstood the article, or am I possibly overreacting? Personally, I’m still sold on the benefits of sulforaphane, but maybe it’s worth looking at spacing the doses out (exactly how far, I don’t really know). Anyone have any thoughts, rebuttals, or suggestions?