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Humans with a polymorphism that makes more of the foxo3 gene have a 2.7-fold increased chance of being a centenarian (that is, living to be at least 100 years old). The reason why having more foxo3 is associated with longevity is because it turns on a whole host of genes that are involved in stress resistance making you more resilient to the damage associated with aging that occurs every day. One more reason to eat your salmon!