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Interestingly, PI3K/AKT/FOXO seem to relevant in development/susceptibility of both acne and depression, this may explain part of the link. Isotretinoin also seem to exert some of it’s effects on this pathway.
[FOXO & depression]
[FOXO & Acne]
Interesting correlation. I wonder if it has to do more with teenage hormones, etc… more than body image issues.
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