… In these healthy non-trained participants (n=99), psychometric fatigue judged by visual analogue scales (VAS) was significantly decreased in the H2 group after mild exercise. When each group was divided into two subgroups, the subgroup with higher VAS values was more sensitive to the effect of H2. In experiment 2, trained participants (n=60) were subjected to moderate exercise by cycle ergometer in a similar way as in experiment 1, but exercise was performed 10 min after drinking H2 water. Endurance and fatigue were significantly improved in the H2 group as judged by maximal oxygen consumption and Borg’s scale, respectively. Taken together, drinking H2 water just before exercise exhibited anti-fatigue and endurance effects.