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A double-blind, placebo-controlled trial finds that supplementation with spermidine, a compound known to enhance autophagy, improved memory performance in older individuals after three months compared to placebo (pilot study).

The dose of spermidine used in this study was 1.2 mg per day.

Foods rich in spermidine are wheat germ (440 mg/kg), aged cheese (200 mg/kg for 1-year old cheddar), legumes (approx. 100-300 mg/kg for dried soybeans, natto and tempeh and 65 mg/kg for cooked green peas), mushrooms (89 mg/kg), chicken liver (49 mg/kg), broccoli and cauliflower (aprox. 30-40 mg/kg), mango (30mg/kg), celeriac (27 mg/kg) as well as whole grains and potatoes (approx. 10-50 mg/kg).

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    Is this study you’re referring to? One of the authors Slaven Stekovic presented this at a conference I was at recently. Any idea when Spermidine will be commercially available? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492385/

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      Top 5 food sources of Spermidine (mg/portion) in the Dietist XP food portion size in g mg/portion of Spermidine Soybean, cooked 190g 9.7mg  Peas, green 140g 9.1mg  Pear 125g 6.6mg  Lentil soup 250g 5.5mg  Mushroom 50g 4.4mg –easy to get 1.2 / day from healthy foods data extracted from Table 2: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022763/