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This article
“A Reduced Form of Nicotinamide Riboside Defines a New Path for NAD+ Biosynthesis and Acts as an Orally Bioavailable NAD+ Precursor,”
https://www.sciencedirect.com/science/article/pii/S2212877819309160
says that “NRH acts as a more potent and faster NAD+ precursor than NR in mammalian cells and tissues.” Would love to hear your thoughts on it.
Can NR or NMN be absorbed into the bloodstream sublingually? If so, then is that a pathway by which either could be converted into NAD+ without the limiting effect of the liver feedback mechanism?
I’m also concerned after listening to Sinclair that sourcing non-degraded NMN is not practical yet. He basically comes out and says people are likely getting degraded products, no matter how expensive.
Nuchido claims that their product, Nuchido TIME+, boosts NAD+ four times more than any other product. https://nuchido.com/products/nuchido-time
Their evidence is here: https://nuchido.com/pages/science Can their claims be valid? Please delete my comment if it is your policy not to speak for or against any commercial product.
After listening to Sinclair, I’m a little concerned about my sourcing for NMN. If it hasn’t been processed, stored and shipped properly it not only could be useless, but dangerous? DS stated that when NMN goes bad it can actually shut off sirtuins? That is scary!
What are your thoughts on Nicotine competing with NAD+ in cells and thereby reducing SIRT1? Could this be one of the causes for reduced lifespan in smokers? If so, would that also affect lifespan for people smoking e-cigarettes?
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This article “A Reduced Form of Nicotinamide Riboside Defines a New Path for NAD+ Biosynthesis and Acts as an Orally Bioavailable NAD+ Precursor,” https://www.sciencedirect.com/science/article/pii/S2212877819309160 says that “NRH acts as a more potent and faster NAD+ precursor than NR in mammalian cells and tissues.” Would love to hear your thoughts on it.
Can NR or NMN be absorbed into the bloodstream sublingually? If so, then is that a pathway by which either could be converted into NAD+ without the limiting effect of the liver feedback mechanism?
I’m also concerned after listening to Sinclair that sourcing non-degraded NMN is not practical yet. He basically comes out and says people are likely getting degraded products, no matter how expensive.
Looking into things I found that there is another NAD+ precurser as indicated here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398323/
I wonder why this has not entered the discussion. Something we are missing?
Nuchido claims that their product, Nuchido TIME+, boosts NAD+ four times more than any other product. https://nuchido.com/products/nuchido-time Their evidence is here: https://nuchido.com/pages/science Can their claims be valid? Please delete my comment if it is your policy not to speak for or against any commercial product.
After listening to Sinclair, I’m a little concerned about my sourcing for NMN. If it hasn’t been processed, stored and shipped properly it not only could be useless, but dangerous? DS stated that when NMN goes bad it can actually shut off sirtuins? That is scary!
What are your thoughts on Nicotine competing with NAD+ in cells and thereby reducing SIRT1? Could this be one of the causes for reduced lifespan in smokers? If so, would that also affect lifespan for people smoking e-cigarettes?