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    Are there any data about exercise during FMD? Is a best practice to abstain for the 5 days?

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      Thanks for the wonderful podcasts. I am curious about the use of glycerol in Dr. Longo’s FMD. Dr. Longo has explained, elsewhere, that glycerol extends the life of yeast when used as an alternate carbon source (alternate to glucose or ethanol) ie glycerol shifts metabolism away from glycolysis towards oxidative phosphorylation thereby mimicking calorie restriction. Other researchers have found similar benefits in some organisms. In the recent Eric Verdin podcast, Dr. Verdin explains (~39 minutes in) the importance of mitochondrial health and hints at a positive role for oxidative phosphorylation. I am hoping the use/role of glycerol and its impact on longevity can be explored somewhere along the line.

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        Referring to different lengths of fasting periods, Dr Longo says “So, what do they have in common? […] they are very different interventions, and they each do something different.”

        I would like to know more about how different fasting periods differ and what the results of them are, including prolonged fasts of a duration longer than 5 days. Does anyone have resources on this?

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          Great podcast! I’m keen to try a 5 day water fast. Can you confirm if it’s ok to take magnesium supplements? Are there any other supplements than can be consumed on a strict water fast?

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            I’ve done a 5 day fast with broth and add a little salt. Once you get in ketosis you’ll start to lose a little sodium. You can take a multivitamin if it doesn’t make you nauseous on an empty stomach, but you don’t have to take anything. Especially, if you are in relative good health prior to starting the fast. I place my patients on a broth diet often with great results. Dr. Patrick, can correct me if I am wrong.

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              Thanks! I will take magnesium / salt water, but may skip the broth and multivitamins as they will both technically ‘break’ the fast (?).

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            Very interesting podcast. The fast-mimicking diet is interesting, but I usually don’t have much trouble doing a 5-day fast with just a little coffee in the morning and a cup of bone broth in the evenings. Were there any benefits to using the fast-mimicking diet that aren’t also a benefit of actually fasting, or even more so?

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              I have heard that FOXOs have been linked with the development of major depression https://www.ncbi.nlm.nih.gov/pubmed/26279492. Any comments/findings from your perspective with regards to this and FMD benefits?

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                Is this a good FMD meal plan or should I change anything?

                https://prnt.sc/la0t2e

                https://www.eatthismuch.com/dietset/768203578/

                I did not put any micronutrient information in it but I assumed that hitting all micronutrients perfectly is not important. Is that true or should I adjust something, and what should I aim for?