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could K2 be gotten with just grassfed butter and cheese? Or is a MK7 or MK4 supplement most beneficial?
There is some K2 in fermented cheeses but the amount is VERY small relative to natto. Supplement is best… MK7 has a longer half-life than MK-4 but many of the clinical trials showing benefits of supplementation have been done using MK4. I supplement with MK-7.
And out of curiosity here how does APO E status affect vitamin K metabolism? It seems that Apo E 4 allele has a negative effect on vitamin K status.
I’m actually writing an academic paper that covers this and more (my next paper is on APOE and Alzheimer’s)! Unfortunately, I can’t talk about it yet (until submit) but you are totally on right track.
I look forward to reading it! This paper seems to indicate that APOE4 has a negative effect on on vitamin K metabolism, http://www.lmreview.com/articles/view/Vitamin-K2-Essential-for-Prevention-of-Age-Associated-Chronic-Disease/
My mom has osteoporosis (and her side of the family tends to) and she has 1 APOE4 allele. This is despite drinking a fair amount of milk. The only thing that confused me was this paper saying that “This study demonstrates that a superior vitamin K status is associated with the apoE4 genotype in healthy older individuals from China and the UK.”
PMID: 16351773 [PubMed - indexed for MEDLINE]“ http://www.ncbi.nlm.nih.gov/pubmed/16351773
The the research I have done on this leads me to the conclusion that APOE4 carriers should a take K2 supplement. The China study you linked seems like an outlier as I have seen multiple studies showing the opposite. Thanks for the link.
the key word here seems sto be “healthy”. i.e. the study carlsonbjj linked to mentions that superior vitamin K status is associated with the APOE4 genotype in HEALTHY older individuals.
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