Notch 1, a gene linked to inflammation in the aorta, may contribute to abdominal aortic aneurysm. (2012) Digest
From the article:
Inflammation is a hallmark of AAA [abdominal aortic aneurysm]. The Notch 1 gene is involved in many developmental processes in humans and studies have shown its signaling pathway to be active in several inflammatory diseases.
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Findings showed that mice that had a genetic deficiency of Notch1 or received a chemical Notch inhibitor had less inflammation in the aorta and had a reduced incidence of AAA.
“Our data suggest that Notch 1 is an important player in the inflammatory process in the setting of AAA,” says Dr. Hans. “Treatment with Notch 1-specific inhibitors may be a potentially promising strategy for slowing aneurysm development.”