Featured in Science Digest #151

A single session of aerobic exercise boosts brain-supporting protein, BDNF, by 42% in older adults, improving verbal memory. Digest

https://www.sciencedirect.com/science/article/pii/S1728869X25000292

Aging often brings about a decline in memory and cognitive skills, making maintaining brain health more challenging. But exercise is a powerful tool that can support brain function and help delay age-related memory loss. A recent study found that older soccer players experienced a 42% increase in brain-derived neurotrophic factor (BDNF)—a protein that supports brain growth and memory—after aerobic exercise, suggesting that staying active into old age offers meaningful brain benefits.

The study involved 29 male soccer players divided into two groups: young adults aged 19 to 30, and older adults aged 46 to 71. Researchers measured verbal and non-verbal memory performance, along with blood levels of BDNF and its receptor, TrkB, before and after a single 60-minute session of aerobic exercise.

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After exercise, BDNF levels increased by 42% and TrkB levels by 44% in the older group, indicating a robust biological response to activity despite age. Verbal memory improved by 15% in both groups, while nonverbal memory remained unchanged. Although older players responded well to exercise, they started with lower baseline levels of BDNF and TrkB. They performed worse on non-verbal memory tasks, underscoring age-related differences in brain function.

These findings suggest that regular participation in aerobic activities like soccer help preserve brain health with age by enhancing BDNF production, a key factor in memory and cognitive performance. Learn more about how exercise boosts BDNF in The Cognitive Enhancement Blueprint, a members-only perk.