A double-blinded placebo controlled trial finds that probiotic supplementation for 1 year resulted in 50% less bone loss compared to placebo.

The elderly women with low bone-density supplemented with L. reuteri 6475 (1x1010 CFU/day) or placebo for 12 months. There was a 50% reduction in total bone density in the distal tibia. The two groups were similar regarding all anthropometric and lifestyle factors.