Estradiol use may be associated with a lower risk of blood clot formation in the leg veins and lungs than conjugated equine estrogen use. (2013) Digest
www.sciencedaily.com
From the article:
To further understand the differences in risk, the researchers also measured clotting (coagulation) factors in the blood of women who did not develop a clot. The researchers found that, compared with estradiol users, conjugated equine estrogen users had levels of blood factors that made them more prone to form blood clots.
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The researchers also investigated other cardiovascular events:
– The risk of having a heart attack was somewhat – but not significantly – higher in women using oral conjugated equine estrogens than in those using oral estradiol.
– No difference was seen in the risk of stroke.