Featured in Science Digest #151

An okra-enriched diet could counteract metabolic disruptions caused by overfeeding in infancy. Digest

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Early-life nutrition influences lifelong health, and excessive calorie intake in infancy can set the stage for obesity, insulin resistance, and chronic inflammation. However, okra, a vegetable rich in anti-inflammatory and antioxidant compounds, may help counteract these harmful effects. A recent study found that rats overfed during infancy became obese and glucose intolerant, but those fed an okra-enriched diet avoided these issues entirely.

Researchers raised a group of rat pups in small litters, where each pup had greater access to milk, and another group in normal-sized litters. After weaning, the pups ate either a standard diet or one supplemented with 1.5% okra powder. The researchers tracked food and water intake, weight gain, glucose tolerance, insulin response, and inflammation in the animals' brains and fat tissue.

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Pups from small litters (who consumed more calorie-dense milk) gained more weight, ate more food, and developed obesity, high blood sugar, high triglycerides, and insulin resistance in the brain. These rats also showed elevated levels of pro-inflammatory molecules in the hypothalamus, including 78% higher interleukin-6 levels. But when these same rats consumed the okra-supplemented diet, they avoided these metabolic disruptions.

These findings suggest that okra helps protect against long-term metabolic harm caused by early overfeeding in early life. Breastfeeding also helps support a normal body weight and metabolism. Learn more in our overview article.