Injecting small amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer, including distant, untreated metastases in the animals. 87 of 90 mice were cured of cancer.
The method works to reactivate the cancer-specific T cells by injecting microgram amounts of two agents directly into the tumor site. Some of these tumor-specific activated T cells then leave the original tumor to find and destroy other identical tumors throughout the body.
A pilot clinical trial is underway and is expected to recruit about 15 patients with low-grade lymphoma.