* Download comes with a free subscription to our newsletter. You can unsubscribe any time. You will not get duplicate emails if you download more than one report.

  1. 1

From the article:

The team tested conditional knockout mice, or cko mice, with ovaries removed but supplemented with estradiol pellets or a placebo. In contrast to wild-type mice, the cko mice without the natural ovarian hormones estradiol showed symptoms of severe skin inflammation.

Once these mice were given estradiol, the production of IL-17A and IL-1β cytokines in neutrophil and macrophage immune cells was reversed, reducing the inflammation. This effect was also observed in human neutrophils in vitro.

What intrigued the researchers was how the lack of estrogen receptors in immune cells made estradiol ineffective against the cytokines.

View full publication

  1. You must first login , or register before you can comment.

    Markdown formatting available