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There have been several associative studies that have found that caffeine consumption is associated with a 36% lower dementia risk. But this study was an in-vitro study (meaning it was done in cultured cells) so it is too early to say whether drinking a cup of coffee will boost the activity of this enzyme in humans but hopefully, future studies will illuminate this. It is likely that there may be several different compounds present in coffee that may have a positive effect on cognitive function. On a side note, retinoic acid (vitamin A) was also shown to boost the activity of this enzyme although to a lesser degree than caffeine.