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Hi, I am new to polymorphisms and would like any input with regards to my results from my comprehensive report. I have the PEMT rs7946(T;T), MTHFD1 rs2236225(C;T), FUT2 rs602662(G;G) and the MTRR rs1801394(A;G). Should I run other tests, supplement or take action of some sort? Is there a service I can consult with to help explain? Sounds like I could be choline and B deficient which may explain elevated AST & ALT levels and other ongoing issues I’ve had. Thanks for any help.

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    I have a lot of questions about this too, and I’m sure others do as well. I have the homozygotic version of MTHFR and two other genes that indicate a messed up folate/choline metabolism. I started taking methylfolate a few days ago but haven’t really noticed any effects. Let’s keep each other posted if we get some answers! This may also be helpful for you, if you haven’t seen it yet: https://www.youtube.com/watch?v=bVV2RFEiqN4

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      What brand and dose are you taking of methylfolate? Thanks so much.