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to the editor: in the recent work of Bielohuby et al. (1) published in this journal, the authors discussed the hypothesis that the restriction of carbohydrates, substituted by the high consumption of fats, induces a state of glucose intolerance and insulin resistance in rats, which was demonstrated through diverse methodologies, including the hyperinsulinemic euglycemic clamps. It was further shown that these effects are independent of the visceral adipose mass and caloric consumption.