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“ Rosemary extract significantly reduced total and phosphorylated/activated Akt, mTOR and p70S6K levels ”.

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    Worth checking if “significantly reduced” is a case of the same misleading ambiguity covered here, as linked in this other article. (Probably)

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      https://pdfs.semanticscholar.org/55a2/5f0584db5a869e9765011c56ea61f9374ea1.pdf Within the first few paragraphs of pg 10 of 32 the authors make mention of in-vitro studies, including that of Moore et al. that do show an effect on the mTOR pathway. At this point, it is not just postulation that derivatives of Rosemary Extract have a highly specific inhibitory effect on mTOR in some cancer cell lines.{The caveat, however, is that I could only find 2 studies from a simple google search that show this and surely there are other plants out there that might have the same effect. Also, I would like to know the dose required and if there are toxic effects on normal cells.} Of course, upon reading the provided article above, one will find that mTOR is not the only pathway involved in RA induced apoptosis of cancer cells. However, what is interesting is that it inhibits mTOR at all. Here is another study showing the same effect https://www.ncbi.nlm.nih.gov/pubmed/25178877. Also, on pg 7 of 32 an in-vitro study found that the A549 cell mTOR signalling was downregulated in lung adenocarcinoma. Several studies have found very intriguing results when testing the effects of Rosemary upon different processes within not just the body, but the brain as well. I wonder if it has to do with its antioxidant properties. It is fascinating really. Anyways, for the purposes of guarding against synonymizing the word significant with redundancy or overly-robust correlations, effects etcetera… I agree with you definitely. I think it is better to find other words to use! Thank you for presenting your viewpoint. I found your paper useful.

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        I am not great at reading results of studies, but would this have a negative impact on weight training/putting on muscle? Should Rosemary be avoided surrounding exercise to not interfere with those goals?