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Curcumin is known to have potent anti-inflammatory effects… thus, since depression seems to be associated with inflammatory status, maybe this effect should be unsurprising! Two doses of phytosomal curcumin were used in this study (250 mg/day and 500mg/day) and both were effective at reducing depressive symptoms. Limitations of this study include the fact that changes in symptoms were self-reported… the study did include a placebo, however, and was also double-blinded.