From the article:
“Our team found that high salt consumption lowered levels of circulating beta hydroxybutyrate. When we put beta hydroxybutyrate back in the system, normal blood pressure is restored,” said Dr. Bina Joe, Distinguished University Professor and chair of UT’s Department of Physiology and Pharmacology and director of the Center for Hypertension and Precision Medicine. “We have an opportunity to control salt-sensitive hypertension without exercising.”
The effects may be microbiome mediated. Read the following excerpt from discussion in a Cell spotlight:
Changes in the microbiota, specifically a decrease in Lactobacillus spp., in rats fed a high-salt diet have also been implicated in drivingthe progression of hypertension. The authors found that Lactobacillus spp. and Proteobacteria were reduced and Prevotella spp. were increased by a high-salt diet. The changes in the microbiota were associated with a decrease in gluconeogenesis and ketone metabolism, which was not restored by supplementation with 1,3-butanediol. Interestingly, after 1,3butanediol treatment, Proteobacteria and Prevotella shifted back toward the low-salt relative abundance and also correlated with an increase in protective Akkermansia levels.