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Based on clinical studies, creatine supplementation, particularly when combined with training, may potentially affect glucose uptake. In addition, creatine can maximize exercise capacity on GLUT and AMPK, improving insulin sensitivity. However, there are a very limited number of clinical interventions testing the effects of creatine supplementation in glucose metabolism precluding the prescription of this dietary supplement as part of the treatment of conditions characterized by insulin resistance. Regarding animal studies, the results were largely divergent confirming that species-specific responses do exist in relation to creatine studies. Given the potential of this intervention as an antiglycemic agent, evidenced by (scant) experimental and clinical data, further studies are needed to better understand the effects and underlying mechanism of creatine supplementation in modulating glycemia.
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