Check out the interesting Scientific American article titled, “Brain’s Dumped DNA May Lead to Stress, Depression”. It describes how “genetic material from the mitochondria can trigger an immune response”. Accordingly, when our bodies are chronically stressed our mitochondria’s inherently limited repair mechanisms foster mitochondrial damage. Mitochondrial DNA is released into cell cytoplasm and eventually into the blood to fuel the growing demands on a stressed body’s heart, lungs, and muscles. Once mitochondria is leaked into the blood it binds to the TLR9 receptor on immune cells, made more likely due to its, “bacterial origin and its circular DNA structure”. Immune cells release cytokines and inflammation ensues. It is suggested, therefore, that drugs that improve modulation of cellular energy may improve our defense for affected psychiatric and biological disorders.
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Check out the interesting Scientific American article titled, “Brain’s Dumped DNA May Lead to Stress, Depression”. It describes how “genetic material from the mitochondria can trigger an immune response”. Accordingly, when our bodies are chronically stressed our mitochondria’s inherently limited repair mechanisms foster mitochondrial damage. Mitochondrial DNA is released into cell cytoplasm and eventually into the blood to fuel the growing demands on a stressed body’s heart, lungs, and muscles. Once mitochondria is leaked into the blood it binds to the TLR9 receptor on immune cells, made more likely due to its, “bacterial origin and its circular DNA structure”. Immune cells release cytokines and inflammation ensues. It is suggested, therefore, that drugs that improve modulation of cellular energy may improve our defense for affected psychiatric and biological disorders.
https://www.scientificamerican.com/article/brain-rsquo-s-dumped-dna-may-lead-to-stress-depression/