My daughter needs a good magnesium supplement (she won’t eat a lot of greens - she can’t eat raw veg since she has Oral Allergy Syndrome, everything has to be cooked so much it winds up being unpalatable). I have concerns about contamination issues as well as glycine supplementation. Glycine has been found to be elevated in the CSF of patients with a number of neurodegenerative diseases - Dementia with Lewy Bodies, ALS, & MS. Oral dosing was found to increase CSF glycine levels in patients with various motor neuron diseases including one patient with MSA and there is a case report of gylcine transporter deficiency in Multiple System Atrophy. My father had MSA, I’m starting to have symptoms even though it is not supposed to be hereditary, and my daughter had an episode of Neuroleptic Malignant Syndrome in response to Reglan (some similarities between NMS and sudden death in Parkinson’s). We also are all carriers for a fatty acid oxidation disorder - MCADD; I became symptomatic in my late teens, so far my daughter is not - but I would prefer she avoid MCT. So ideally I would like an Mg supplement that tests clean and doesn’t have glycine or MCT . Thorne’s Mg citrate-malate includes MCT for some stupid reason. Lots of Mg citrate supplements have contaminants according to Labdoor. What’s a mom to do?
To be honest, I’m more worried about brain damage than lung damage - hypoxia and microthrombi are not good for the brain. There’s some research that linked APOE4 to higher risk of severe covid, also - I can see that being a nasty positive feedback for Alzheimer’s risk.
What do you think of the recent study on hydroxycholoquine for prophylaxis using folate as a placebo (I’m assuming it was actually folate and not folic acid)?
Interesting case report from Cedars Sinai on use of NMN in a patient with covid-19:
The patient had a history of chronic hives; mast cells regulate CD4+ T-cell differentiation via an NAD dependent mechanism:
IIRC Dr Patrick’s opinion on trying to increase intracellular NAD via supplementation was that it is not advisable at this time for a healthy person, but might there be use for NAD+ boosters for acute infections or mast cell disorders (or both, as in this case)?
- would an NLRP3 inflammasome inhibitor (e.g., MCC950 or derivatives) be helpful in controlling inflammation in severe covid-19?
- dysfunctional AMPK signalling seems to be involved in most risk factors for severe covid-19; would metformin be helpful for those who can’t/won’t exercise?
- mannitol increases HSP70 and has been reported to restore the sense of smell in Parkinson’s patients; could it be helpful to recovered covid patients in restoring their sense of smell or possibly even with lung fibrosis? Would sauna help / be preferable (not everyone has access to a sauna, though)?
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