[Podcast] Aliquot #140: Should Everyone Cut Out Gluten?
Gluten interacts with the gut barrier in ways that can shift intestinal permeability, but the impact of that shift... ... aliquot gut gluten intestinal permeability diet
Listen now[Podcast] Will George Church reverse aging │ Dr. George Church
In this clip, Dr. George Church discusses how aging might be reversed and what animal research can tell us about human aging. ... genetic engineering technology aging stem cells genetics
Watch now[Topic] Beta-hydroxybutyrate
[toc position='left'] Background [tweetbox text='"Because BHB is involved in such foundational cellular functions as gene regulation, increasing BHB concentrations may be protective against a wide range of diseases."' tweet='"Because BHB is involved in such foundational cellular functions as gene regulation, increasing BHB concentrations may be protective against a wide range of diseases." https://www.foundmyfitness.com/topics/beta-hydroxybutyrate'] Beta-hydroxybutyrate (BHB) is an endogenous (i.e., produced by the body) ketone produced via the breakdown of fats during times of carbohydrate sc... butyrate exercise fasting aging ketosis
Read more[Podcast] Omega-3 enhances red blood cell biology — improving red cell distribution width
In this clip, Dr. Bill Harris highlights a novel area of research — the role omega-3s play in altering red blood cell biology. ... omega-3 aging heart disease
Watch now[Podcast] Fasting as an evolved mechanism for repair on internal organs | Valter Longo
Dr. Valter Longo discusses how cellular repair mechanisms may have evolved during times of fasting, but are latent in times of food abundance. ... fasting stem cells immune system multiple sclerosis autophagy evolution
Watch now[Podcast] How the cell prioritizes and targets organelles and protein aggregates for degradation by autophagy
Dr. Guido Kroemer describes the cellular process of autophagy and what factors trigger its activation. ... autophagy cancer mitochondria neurodegeneration cardiovascular
Watch now[Story] Beta-hydroxybutyrate production from fasting or a ketogenic diet may reduce the production of senescent cells associated with vascular aging
Fasting or beta-hydroxybutyrate administration reduces cellular senescence. Beta-hydroxybutyrate (BHB) (https://foundmyfitness.com/topics/beta-hydroxybutyrate) is a ketone produced by the body during times of carbohydrate scarcity such as those encountered while practicing a ketogenic diet (https://www.sciencedirect.com/science/article/pii/S1550413117304904), fasting (https://www.mdpi.com/2072-6643/12/4/1194), or exercise (https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2707428), which have all demonstrated the ability to extend healthspan and lifespan. However, the precise effect... aging ketosis heart disease dna damage fasting ketogenic diet
Read more[Story] The production of acetoacetate when we burn fat protects from a damaging metabolite generated from sugar metabolism.
A metabolic byproduct of sugar metabolism called methylglyoxal has been linked to age-related diseases such as type 2 diabetes, Alzheimer's disease, and cancer. People that were fasted for one night and had higher levels of acetoacetate also had higher levels of a compound called 3-HHD which forms through the detoxification process of methylglyoxal. ... ketosis diabetes sugar
Read more[Story] Skin cells reprogrammed into stem cells & engineered to deliver a cancer drug shrank brain tumors 20- to 50-fold.
Scientists are exploiting the fact that neural stem cells are attracted to cancer cells because they emit a signal that is similar to a damaged neuron. The stem cell migrates to the cancer cell in order to repair the damage. If these stem cells are engineered to deliver a drug that can kill the tumor, it is a highly specific way of only selectively killing the tumor cells without damaging normal cells. In this case, in the brain. The drawback has been that it is hard to get neural stem cells but with new technology that can turn a skin cell into any type of stem cell, this overcomes that barri... technology cancer stem cells neurons
Read more[Story] Stem cells from one monkey regenerates the damaged heart of another monkey with no sign of immune system rejection.
The stem cells were made from skin cells from one monkey which was generated into cardiac cells and transplanted to another monkey with a damaged heart. The transplanted cells improved the heart’s ability to contract after an induced heart attack and integrated with no sign of immune rejection by the recipient’s immune system. ... heart disease stem cells
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