Increased in memory biomarker Cathepsin B confirms aerobic exercise helps cognitive function in older adults

From the article:

Verbal learning and memory correlated positively with change in cathepsin B (CTSB) but was not related to BDNF or klotho. The present correlation between CTSB and verbal learning and memory suggests that CTSB may be useful as a marker for cognitive changes relevant to hippocampal function after exercise in a population at risk for dementia.[…] CTSB, a lysosomal enzyme, is secreted from muscle into circulation after exercise and is associated with memory function and adult hippocampal neurogenesis. Older adults with cognitive impairment have lower serum and brain CTSB levels.