Spermidine, a compound very high in fermented soybeans called natto, prevented liver cancer and extended lifespan by 25% in mice.
www.sciencedaily.com
Spermidine is also pretty high in fermented cheeses and mushrooms.
Spermidine causes damaged cells to be cleared through a process known as autophagy which has itself been shown to extend healthspan of animals.
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In this study, mice had to be fed spermidine from weaning in order to get the 25% lifespan extension. Those mice that were fed spermidine starting in early adulthood only had a 10% increase in lifespan.